Expression of RANKL and OPG in saliva of type 1 diabetes mellitus patients in Thailand : a pilot study

Not Applicable

• Conditions: Diabetes mellitus type 1 patients have higher expression of RANKL and lower expression of OPG than healthy subjects.Diabetes mellitus type 1 patients have poorer periodontal conditions than healthy; Expression of RANKL and OPG; saliva; type 1 diabetes mellitus patients; Probing Depth; Clinical attachment level; bleeding on probing

• Registration Number: TCTR20170929001
• Lead Sponsor: Faculty of Dentistry, Mahidol University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2017-09-29
• Study Completion: 2017-12-29
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Pending (Not yet recruiting)
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

Type 1 diabetes mellitus patients which HbA1C 7-12% have been treated at Siriraj hospital.
Control group is healthy patients who have age-matched with Type 1 diabetes mellitus patients.

Exclusion Criteria

1. Patient who have been periodontitis as a manifestation of systemic diseases such as Leukocyte adhesion deficiency, Ehler danlos syndrome, neutropenia, Down syndrome, Papillon-Lefvere syndrome, Chediak-Higashi syndrome, Histiocytosis syndrome, Glycogen storage disease, Infantile genetic agranulocytosis, Cohen syndrome, Hyphosphatasia, and leukemia
2. Immunodeficiency patients
3. Patients who cannot cooperate due to a lack of psychological
or emotional maturity and/or mental, physical,
or medical disability
4. Patients who take medication that effecting periodontium, bleeding disorder, and infection
5. Patients who recieved bisphosphonate
6. Patients who recieved orthodontics treatment
7. Smoking
8. Pregnant
9. Patients who have deciduous teeth
10. Patients who recieved periodontal treatment within 6 months

Study & Design

• Study Type: Observational
• Study Design: Not specified