This Present Study Can be Used by Clinicians Who Treat Psychiatric Patients: Dentists Might Expect Xerogenic Side Effects of Specific Psychiatric Drugs Which Can Affect Dental Treatment, and the Results Can Help Psychiatrist to Choose the Less Xerogenic Psychiatric Medication

Completed

• Conditions: Psychiatric Disorders; Xerostomia Due to Hyposecretion of Salivary Gland

• Registration Number: NCT06920472
• Lead Sponsor: Semmelweis University

Brief Summary

The goal of this observational study is to learn about the effects of psychiatric drug therapies on intra- and extra-oral sicca symptoms and salivation. The main question that it aims to answer is:

Does taking psychiatric medication cause oral dryness and/or any changes on whole and minor saliva secretion? Participants taking psychiatric medication answered a 16-question questionnare, and their saliva production was measured by Periotron device and by spitting method.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-01-01
• Primary Completion: 2018-01-01
• Study Completion: 2018-01-01
• Status Verified: 2025-01
• Study First Submitted: 2025-01-15
• Study First Submitted QC: 2025-04-08
• Study First Posted: 2025-04-09
• Last Update Submitted: 2025-05-19
• Last Update Posted: 2025-05-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 361

Inclusion Criteria

In the psychiatric group, the inclusion criteria was taking specific psychiatric medications.

Exclusion Criteria

In the control group the exclusion criteria was reporting any diseases and taking medicines.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Unstimulated whole saliva flow rate (UWS)	through study completion, an average of 1 year	UWS was determined using the "spitting" method (Sreebny 2000). Whole saliva was collected for 5 minutes into a previously weighted empty cup, and then measured again after collecting the saliva. The results are in ml/min.
Minor salivary gland (MSG) secretions	Through study completion, an average of 1 year	Palatal and labial MSG flow rates were measured by the Periotron 8010® (Oraflow Inc. Amytiville, USA) device with filter paper discs. The results are transferred into µl/cm2/min.