Effects of N-acetylcysteine on the expression of UCP1, didinase type 2 and 3, as well as thyroid hormone receptors alpha and beta in visceral adipose tissue of obese adults

Phase 3

Recruiting

Conditions: Obesity adults.
Overweight and obesity

Registration Number: IRCT20220727055563N2

Lead Sponsor: Shahid Beheshti University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 50

Inclusion Criteria

Obese people with a body mass index greater than or equal to 30 kg/m2.Age over 25 years
Non-pregnant and lactating
Not suffering from chronic and acute inflammatory, and infectious diseases
Not suffering from high blood pressure and vascular diseases
Not receiving alcohol and smoking

Exclusion Criteria

Receiving weight loss and antioxidant drugs and supplements in the last three months
Participating in other clinical trial studies at the same time as the present study.
Adherence to weight loss diets during the last three months.
History of gastrointestinal or bariatric surgeries.

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Expression of UCP1 genes. Timepoint: At the end of week 6. Method of measurement: Using PCR (polymerase chain reaction).

Secondary Outcome Measures

Name	Time	Method
Expression of didinase type 2 and 3 genes. Timepoint: The end of week 6. Method of measurement: Using PCR (polymerase chain reaction).;Expression of alpha and beta thyroid hormone receptor genes. Timepoint: The end of week 6. Method of measurement: Using PCR (polymerase chain reaction).;Serum level of thyroid hormones (TSH, T3 and T4). Timepoint: At the beginning of the study and at the end of week 6. Method of measurement: Blood sampling and measurement by ELISA method.