Oxygenation and Perfusion in Patients With Acute Migraine Attacks

Completed

• Conditions: Migraine; Status; Migraine; Migraine With Aura

• Registration Number: NCT03536936
• Lead Sponsor: Insel Gruppe AG, University Hospital Bern

Brief Summary

The aim of the study is to retrospectively evaluate brain perfusion and oxygenation in acute migraine attacks. Magnetic resonance perfusion and susceptibility weighted imaging are the technics to measure perfusion and oxygenation respectively.

Detailed Description

The aim of the study is to demonstrate a possible correlation between areas of hypoperfusion and prominent cortical veins during migraine attacks.

These focal ares of altered vascular supply of the brain will be evaluated for correlation with topograhy of symptoms.

Study Timeline

• Study Start: 2010-01-01
• Primary Completion: 2018-04-30
• Study Completion: 2018-04-30
• Status Verified: 2018-05
• Study First Submitted: 2018-05-14
• Study First Submitted QC: 2018-05-14
• Last Update Submitted: 2018-05-14
• Study First Posted: 2018-05-25
• Last Update Posted: 2018-05-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 1000

Inclusion Criteria

final clinical diagnosis of migraine

Exclusion Criteria

brain tumors, seizures/epilepsy, confirmed cerebral infarct from cerebral atery occlusion, sinus vein thrombosis;

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Focal cerebral hypoperfusion and elevated oxygenation in acute migraine attack	Patients, who are admitted to hospital, undergo magnetic resonance imaging within 5 days of migraine attack; time frame: symptoms to imaging : 5 days;	Focal cerebral hypoperfusion and elevated oxygenation in acute migraine attack, measured with visual scores on imaging, using a consensus between two readers