Assessment of Choline levels in focal nodular hyperplasia (FNH), hepatocellular adenoma (HCA), and hepatocellular carcinoma (HCC) using proton Magnetic Resonance Spectroscopy. - Choline levels in livertumors.

Academisch Medisch Centrum0 个研究点目标入组 15 人开始时间: 待定最近更新: 2024年5月6日

适应症

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•1. Affirmed diagnosis of FNH, HCA or HCC based on:
•- Histopathological proof
•- If no histological proof was obtained: results of imaging modalities characteristic for FNH, HCA or HCC. These characteristics of MR and CT imaging include:
•* HCA: Hypervascular lesion in the arterial phase and signs of bleeding and/or fat within the lesion.
•* FNH: Hypervascular lesion in the arterial phase, and the presence of a central scar.
•* HCC: Hypervascular lesion in the arterial phase, followed by wash-out during the portal or late phase AND positive patient history for risk factors in HCC development including hepatitis B and C, haemochromatosis, alcohol abuses and cirrhosis OR elevated alpha fetoprotein 1.
•2. Size of the lesion: > 2 cm.
•3. 18 years of age or older.
•4. Before patient registration, written informed consent must be given according to ICH/GCP, and national/local regulations.

•1. Contraindications for MR imaging:
•- Pacemaker, medicine pump, neurostimulator, claustrophobia, iron slivers in the eye, brace.
•- Irremovable body piercing, iron particles in the body.
•- Patients with extreme obesity (will not fit in the bore of the MRI)

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