Effect of Intravenous Acetaminophen on Postoperative Morphine Consumption in Benign Open Abdominal Gynecological Surgeries: A double-blind, randomized, placebo-controlled trial

Not Applicable

Recruiting

• Conditions: Patients undergoing elective benign open abdominal gynecological surgery; intravenous acetaminophen; acetaminophen; abdominal gynecological surgery; hysterectomy; postoperative pain; benign gynecological surgery

• Registration Number: TCTR20200512002
• Lead Sponsor: Faculty of Medicine, Chiang Mai University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2020-05-12
• Study Completion: 2021-05-31
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Female
• Target Recruitment: 100

Inclusion Criteria

1.Women aged 18-65 years old
2.Patients who undergoing elective benign open abdominal gynecological surgery
3.American Society of Anesthesiologists (ASA) Class I-III

Exclusion Criteria

1.Patients with known allergy to acetaminophen, parecoxib, sulfonamides, aspirin or opioids
2.Patients with either acute or chronic liver disease (defined as abnormal rising AST ALT, hypoalbuminemia, prolonged INR, or evidence from imaging diagnosis)
3.Patients with moderate to severe pain before surgery
4.Third trimester pregnant patients or lactation period
5.Patients receive any additional neuraxial block or peripheral nerve blocks for pain control
6.Patients with history of opioid abuse or chronic opioid use for greater than 3 months
7.Patients with suspected malignant gynecological disease intraoperatively and undergo extended lymph node dissection or complete surgical staging
8.Patients with contraindication to parecoxib (post CABG surgery, established ischemic heart disease, peripheral arterial disease and/or cerebrovascular disease, inflammatory bowel disease, Child-Pugh score ≥ 10, active peptic ulcer/ GI bleeding, known hypersensitivity to sulfonamides)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Cumulative postoperative morphine consumption within 24 hours 24 hours of postoperative Morphine consumption

Secondary Outcome Measures

Name	Time	Method
length of hospital stay between two groups during hospitalization length of hospital stay,time to first flatulence and first defecation after surgery between two groups during hospitalization time to first flatulence and first defecation,time to first ambulation between two groups time to first ambulation time to first ambulation,Time to first dose morphine requirement time to first dose morphine time to first dose morphine,Adverse effects of acetaminophen, morphine, parecoxib during hospitalization patient report, observation,Postoperative pain at rest 1,4,8,12,16,20,24,48 hours postoperatively Numeric rating scale