The Effect of Aerobic Exercise in Overweight and Obese Women

Not Applicable

Completed

• Conditions: Obesity; Overweight

• Registration Number: NCT04205981
• Lead Sponsor: Lithuanian Sports University

Brief Summary

Study design The study was designed as a prospective controlled randomized trial. Participants were randomly assigned to one of two groups. In the experimental group, participants (n = 17) received 8-week aerobic exercise intervention without nutrition modifications. In the control group, participants (n = 16) did not undergo any intervention and were instructed to maintain their regular physical activity and diet regime for 8 weeks.

Experimental measurements: Anthropometric measurements, Measurement of BDNF, Cardiac autonomic responses, Measurement of aerobic fitness, Measurement of cognitive functions.

Detailed Description

Not available

Study Timeline

• Study Start: 2017-09-01
• Primary Completion: 2019-09-30
• Study Completion: 2019-09-30
• Status Verified: 2019-12
• Study First Submitted: 2019-12-18
• Study First Submitted QC: 2019-12-19
• Last Update Submitted: 2019-12-19
• Study First Posted: 2019-12-20
• Last Update Posted: 2019-12-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 33

Inclusion Criteria

1. obese women (BMI) > 25 kg/m2;
2. exhibiting weight stability (body weight change < 2 kg) for at least 2 months prior to enrollment;
3. with a sedentary lifestyle (regular exercise < 1 h/week);
4. had no medical condition that would affect study results and limit physical activity;
5. not undergoing lactation;
6. who were not pregnant or postmenopausal.

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Waist and hip circumference	8 weeks	Waist circumference was measured to the nearest 0.1 cm, in duplicate, at the level of the iliac crest at the end of the normal expiration. Hip circumference was measured at the maximum protuberance of the buttocks. Waist and hip circumferences were measured at the nearest 0.5 cm.
Resting blood pressure	8 weeks	was measured using a digital electronic blood pressure monitor (Microlife BP A100, Widnau, Switzerland)
Weight	8 weeks	weight (TBF-300 body composition scale; Tanita, UK Ltd., UK) was measured while the participants wore only underwear and were barefoot.
Blood brain-derived neurotrophic factor (BDNF)	8 weeks	Venous blood samples (5 mL) were collected and allowed to clot at room temperature. Serum was then separated by centrifugation for 15 min at 1,200 g (room temperature) and stored at -80°C until analysis. BDNF were measured using an enzyme-linked immunoassay system (Gemini; Stratec Biomedical, Birkenfeld, Germany).
Cognitive performance	8 weeks	Automated Neuropsychological Assessment Metrics Version 4 (ANAM-4; Vista Life, USA) was used to measure neurocognitive skills: motor reaction time, mental flexibility, mathematical processing, working memory, visual scanning and associative learning skills. Participants were familiarized with the test battery twice before the experiments.
Maximal oxygen uptake	8 weeks	Aerobic fitness was assessed by a graded exercise test on an electronically braked cycle ergometer (Ergoselect 100, Ergoline, Bitz, Germany). Standardized verbal encouragement was provided throughout the test to stimulate maximal performance.
Heart rate variability	8 weeks	R-R intervals were recorded using a Polar H7 sensor with a chest strap (Kempele, Finland).

Trial Locations

Locations (1)

Lithuanian Sports University; 🇱🇹 Kaunas, Lithuania