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Clinical Trials/NCT05517109
NCT05517109
Completed
Not Applicable

The Influence of Different Hemodynamic Parameters in First 24 Hours After Intravenous Thrombolysis on Acute Ischemic Stroke Outcomes: a Randomised Clinical Trial

Northern State Medical University1 site in 1 country90 target enrollmentMarch 12, 2022
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ConditionsAcute Ischemic StrokeIntracranial Hemorrhage

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Acute Ischemic Stroke
Sponsor
Northern State Medical University
Enrollment
90
Locations
1
Primary Endpoint
Modified Rankin Scale score
Status
Completed
Last Updated
last year
OverviewInvestigatorsEligibility CriteriaOutcomesSitesSimilar Trials

Overview

Brief Summary

The investigators are suggtesting that lower goals of systolic blood pressure after intravenous thrombolysis may reduce the risk of hemorrhagic complications and improve functional outcomes after acute ischemic stroke.

Registry
clinicaltrials.gov
Start Date
March 12, 2022
End Date
August 31, 2024
Last Updated
last year
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Sponsor
Northern State Medical University
Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • Not provided

Exclusion Criteria

  • Not provided

Outcomes

Primary Outcomes

Modified Rankin Scale score

Time Frame: 90 day after intravenous thrombolysis

Fucntional outcome (Modified Rankin Scale) will be assesed by telephone interview. Score from 0 to 6. Higher scores mean a worse outcome.

Mortality rate

Time Frame: At 90 day after intravenous thrombolysis

Rate of symptomatic intracranial hemorrhage

Time Frame: 7 days after intravenous thrombolysis

Symptomatic intracranial hemorrhage (sICH) according to SITS-MOST study description of sICH

Secondary Outcomes

  • Lengths of stay in ICU(at 90 day after intravenous thrombolysis)
  • Rate of acute kidney injury(28 day after intravenous thrombolysis or at discharge)
  • Change in National Institutes of Health Stroke Scale (NIHSS)(at 28 day after intravenous thrombolysis)
  • Rate of all Intracranial hemorrhage(7 days after intravenous thrombolysis)
  • Lengths of stay in hospital(at 90 day after intravenous thrombolysis)

Study Sites (1)

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