Clinical trial study on rehabilitation of stroke with integrated traditional Chinese and western medicine based on multi-target nerve loop regulation Research Task One: Study on the Effect of Magnetic Regulation of Central and Peripheral Nerve Loop in Early Rehabilitation of Ischemic Stroke Research Task Two: Study 
- Conditions
- stroke
- Registration Number
- ITMCTR2000003892
- Lead Sponsor
- Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- Not specified
1. Patients diagnosed as ischemic stroke by clinical evaluation and comprehensive imaging examinations meet the diagnostic criteria for ischemic stroke;
2. Fugl-Meyer motor function score is confirmed as motor dysfunction;
3. Aged 18-70 years, no gender limit;
4. No cognitive impairment or communication impairment, with a score of 27 or more in the Simple Intelligence State Examination (MMSE);
5. The first onset, the course of illness is 2 days to January./ The first onset, the course of illness is from January to June. / Patients after nerve transfer.
1. Those who have serious systemic diseases such as cardiopulmonary disease and cannot tolerate rehabilitation treatment;
2. Patients with diagnosed psychosis, major depression (suicidal tendency) or epilepsy, and those with family history of psychosis or epilepsy;
3. Existence of serious systemic diseases such as diabetes and uremia;
4. Severe joint contracture;
5. Suffer from any cause of consciousness disorder;
6. According to safety guidelines, there are contraindications for transcranial direct current/magnetic stimulation (TMS/tDCS) and functional magnetic resonance (fMRI) examinations such as: metal foreign bodies in the body or other electronic devices implanted in the body;
7. Defects in hearing or vision may affect assessment and treatment;
8. Use drugs that change the excitability of the cerebral cortex (antiepileptic drugs, sedative hypnotic drugs, etc.).
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Change of Fugl-Meyer motor function score of affected upper limb;
- Secondary Outcome Measures
Name Time Method Electrophysiological testing of the upper limbs on the affected side: motor cortex evoked potential (TMS-MEP), central motor conduction time (CMCT), and cortical resting period (Silent Period) induced by transcranial magnetic stimulation;Daily life (behavioral) ability: International Classification of Functioning, Disability and Health (ICF) General Combination;Assessment of limb spasticity: modified Ashworth score (MAS);Functional Magnetic Resonance Detection: Including Task-design BOLD scan, Resting-state BOLD scan, brain structure phase scan and Diffusion Tensor Imaging (DTI);Functional Near Infrared Imaging (fNIRS);Physical balance: Berg balance scale;Limb motor function: upper limb WOLF motor function score, Fugl-Meyer motor function score;