ACTRN12609000315213
Completed
N/A
Does vibration therapy improve physical function and strength in children and adolescents with mitochondrial disorders or Rett syndrome?
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Mitochondrial respiratory chain disorders
- Sponsor
- Children's Hospital at Westmead
- Enrollment
- 50
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •For the mitochondrial patients \- Children and adolescents aged between 8 – 18 years with a proven mitochondrial respiratory chain disorder, based on positive enzymology in muscle biopsies
- •for the Rett syndrome patients \- Children with Rett syndrome, with known pathogenic Methyl CgP binding protein 2 (MECP2\) mutations, up to the age of 18 years
Exclusion Criteria
- •for mitochondrial patients \- anything more than mild cognitive impairment which would impede the ability of test subjects to comply with testing; severe myopathy preventing subjects from being able to stand on the vibration platform for at least 10 minutes; 25\-hydroxyvitamin D level \< 50 nmol/L; lower limb fracture within the preceding 6 months; use of a medication known to increase bone mass, eg bisphosphonates
- •for Rett syndrome patients \- inability to stand unaided or with the support of a frame on the vibration platform for at least 10 minutes; 25\-hydroxyvitamin D level \< 50 nmol/L; limb fracture within the preceding 6 months; use of a medication known to increase bone mass, eg bisphosphonates
Outcomes
Primary Outcomes
Not specified
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