Does vibration therapy improve physical function and strength in children and adolescents with mitochondrial disorders or Rett syndrome?

Children's Hospital at Westmead0 个研究点目标入组 50 人开始时间: 2009年5月21日最近更新: 2020年1月13日

适应症

试验速览

暂无简介。

•For the mitochondrial patients - Children and adolescents aged between 8 – 18 years with a proven mitochondrial respiratory chain disorder, based on positive enzymology in muscle biopsies
•for the Rett syndrome patients - Children with Rett syndrome, with known pathogenic Methyl CgP binding protein 2 (MECP2) mutations, up to the age of 18 years

•for mitochondrial patients - anything more than mild cognitive impairment which would impede the ability of test subjects to comply with testing; severe myopathy preventing subjects from being able to stand on the vibration platform for at least 10 minutes; 25-hydroxyvitamin D level < 50 nmol/L; lower limb fracture within the preceding 6 months; use of a medication known to increase bone mass, eg bisphosphonates
•for Rett syndrome patients - inability to stand unaided or with the support of a frame on the vibration platform for at least 10 minutes; 25-hydroxyvitamin D level < 50 nmol/L; limb fracture within the preceding 6 months; use of a medication known to increase bone mass, eg bisphosphonates

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