Cardiac dysfunction in Diabetic patients.

Phase 1

Not yet recruiting

Conditions: Type 2 diabetes mellitus with circulatory complications,

Registration Number: CTRI/2023/11/059500

Lead Sponsor: Kodukula Naga Venkat Bharath

Brief Summary: This study aims to find out the incidence of Left ventricular diastolic dysfunction in patients with Diabetes mellitus type 2. Patients can be newly diagnosed or have a history of DMt2. At presentation all the participants will be tested with serum HbA1c levels which gives us an idea of blood sugar control for the past 3 months. Then the patient will go on to have a 2d echocardiography done, where in parameters for diastolic dysfunction will be measured. Presence or absence of Diastolic dysfunction will be determined by recommendations made by American society of Echocardiography and European Association of cardiovascular Imaging in 2016. The diastolic dysfunction if present will be graded as mild , moderate or Severe and compared to the earlier HbA1c levels. There will be another comparison of severity of diastolic dysfunction between smoking and non smoking Diabetic patients.

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 100

Inclusion Criteria

Patients with DM type 2 .Cases were selected as per the diagnostic criteria laid down by the American Diabetes Association.
Fasting blood glucose (FBS) of 126 mg/dl or higher or a 2-hr postprandial blood glucose (PPBS) level of 200 mg/dl or higher during a 75-gm oral glucose tolerance test or random plasma glucose of 200 mg/dl or higher in a patient with symptoms of hyperglycemia or HbA1c 6.5% or higher.

Exclusion Criteria

Patients with systemic hypertension, coronary artery disease, ischemic heart disease, cardiomyopathy, valvular disorders, connective tissue disorder, CLD, CKD and thyroid dysfunction.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Diabetes mellitus type 2 is associated with left ventricular diastolic dysfunction.	Baseline

Secondary Outcome Measures

Name	Time	Method
Smoking worsens diastolic dysfunction in diabetic patients	Baseline

Trial Locations

Locations (1): Park hospital
🇮🇳
Panipat, HARYANA, India
Park hospital
🇮🇳Panipat, HARYANA, India
Dr Kodukula Naga Venkat Bharath
Principal investigator
7207438198
knvb1998@gmail.com