Protecting the lungs in patients undergoing lung transplantation.

Not Applicable

Completed

• Conditions: Ischaemia-reperfusion injury in lung transplantation.; Anaesthesiology - Other anaesthesiology; Surgery - Surgical techniques; Respiratory - Other respiratory disorders / diseases

• Registration Number: ACTRN12609000763246
• Lead Sponsor: Dr. Enjarn Lin

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2009-09-02
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

All patients listed for lung transplantation (single or double) by the Alfred Hospital lung transplant service.

Exclusion Criteria

Patients treated with sulphonylureas (oral hypoglycaemic agent).
Planned use cardiopulmonary bypass.
Planned combined heart-lung transplantation.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
PaO2/FiO2 ratios as measured by arterial blood gas sampling (arterial blood analysis). Where PaO2 represents partial pressure of oxygen in arterial blood and FiO2 represents fractional of inspired oxygen.[Time 0, 6, 12, 24, 48, 72 hours.]

Secondary Outcome Measures

Name	Time	Method
Right ventricular myocardial performance index (transoesophageal echocardiography parameter)[After chest closure];Incidence of ECMO (extracorporeal membrane oxygenation) requirement. ie ECMO support for oxygenation or not.[During first 72 hours post-operative.];Time to tracheal extubation.[During hospital stay.];Intensive care unit length of stay.[During hospital stay.];Hospital length of stay.[During hospital stay.]