Behavioral Interventions to Reduce Particulate Matter Exposure in Patients With COPD

Not Applicable

Completed

• Conditions: COPD
• Interventions: Behavioral: Five active practices of living rules for responding to fine dust.

• Registration Number: NCT04878367
• Lead Sponsor: Asan Medical Center

Brief Summary

It is a prospective, multi-institutional clinical study and targets patients diagnosed with chronic obstructive pulmonary disease. About 120 subjects (35 at Ilsan Paik Hospital, 35 at Severance Hospital, and 50 at Asan Medical Center in Seoul) will be subject to a random allocation of 1:1. The arbitration group implements living rules for responding to fine dust, supports air purifiers, and only general guidance is implemented in the non-property group. Patients are recruited from Asan Medical Center in Seoul (Songpa-gu, Seoul), Severance Hospital ( Seodaemun-gu, Seoul), and Ilsan Paik Medical Center (Goyang, Gyeonggi-do) for 12 months. During outpatient visits, lung function tests and airway resistance tests shall be conducted, and surveys presented in the research plan shall be conducted.

Detailed Description

It is a prospective and multi-institutional clinical study targeting patients with chronic obstructive pulmonary disease in general.

A total of 120 COPD patients will be recruited from three institutions: Asan Medical Center, Severance Hospital, and Ilsan Paik Hospital. (60/30/30 expected) A panel of COPD patients is established to conduct prospective studies, and measures to mediate recurrence and deterioration of adult chronic respiratory diseases due to exposure to fine dust are presented. Improvement of the lifestyle of the arbitration forces. Detailed research methods such as air purifier support are presented in the research plan.

In addition, a fine dust measurement researcher visits each household to measure indoor fine dust concentration. The measurement method of fine dust concentration will be using the process test method, IoT-based sensors, and direct-to-read measuring devices to measure Air Korea's air pollution. Detailed visit timing and methods are carried out in the manner specified in the research plan.

We collect sputum at every visit and blood at the last visit.

Study Timeline

• Study First Submitted: 2021-04-28
• Study First Submitted QC: 2021-05-06
• Study First Posted: 2021-05-07
• Study Start: 2021-06-01
• Primary Completion: 2022-12-31
• Study Completion: 2023-03-31
• Status Verified: 2023-04
• Last Update Submitted: 2023-04-14
• Last Update Posted: 2023-04-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

• 40 years of age or older
• Waste function test results show FEV1/FVC<0.7, FEV1 <80% of forecast

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Exclusion Criteria

• Patients under 18 years of age with changes in medication (such as inhalants).
• Older people over 80 years of age.
• People with no respiratory symptoms with mMRC 0.
• Who doesn't understand a simple explanation for fine dust exposure devices.
• Someone who disagrees with the study.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
COPD_E	Five active practices of living rules for responding to fine dust.	COPD patients with intervention

Primary Outcome Measures

Name	Time	Method
CAT	12 months	Quality of life
SGRQ-C	12 months	Quality of life

Trial Locations

Locations (1)

Asan Medical Center; 🇰🇷 Seoul, Korea, Republic of