Aortic Dimensions in Turner Syndrome

• Conditions: Turner Syndrome

• Registration Number: NCT00624949
• Lead Sponsor: University of Aarhus

Brief Summary

An observational study of 102 women with Turner syndrome followed for 6 years with a two-yearly examination including ECHO, MRI of the heart and 24 ambulatory blood pressure. It has been found that besides an significantly increased risk of congenital cardiac malformations, TS have an increased risk of developing cardiac disease including the life threatening condition of aortic dilatation and rupture. The aim of the study is to describe the cardiac conditions of TS, evaluate different methods of examination and identify possible risc factors.

Detailed Description

Not available

Study Timeline

• Study Start: 2003-08
• Status Verified: 2008-02
• Study First Submitted: 2008-02-19
• Study First Submitted QC: 2008-02-27
• Last Update Submitted: 2008-02-27
• Study First Posted: 2008-02-28
• Last Update Posted: 2008-02-28
• Primary Completion: 2012-06
• Study Completion: 2012-06

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 102

Inclusion Criteria

• Turner syndrome
• Age 18-70 years

Exclusion Criteria

• Extreme adipositas
• Contraindications to a MRI scan
• Malignant disease

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Aortic diameter at 3 well-defined levels measured by MRI and ECHO	2-yearly for 6 years

Secondary Outcome Measures

Name	Time	Method
24hour ambulatory blood pressure	24h 2-yearly for 6 years