Aneuploidy Rates of in Vitro Matured Oocytes

Completed

• Conditions: Aneuploidy

• Registration Number: NCT03860064
• Lead Sponsor: IVI Barcelona

Brief Summary

In general, nearly 85% of retrieved oocytes are mature and reproductively useful after the retrieval, whereas the remaining percentage are still at metaphase I or germinal vesicle stage (MI: 4% and GV: 11 %, respectively).

The objective of our study is to assess if immature oocytes co-cultured with autologous cumulus cells is a safer strategy than just leaving the oocytes in standard culture.

Detailed Description

Under controlled ovarian stimulation, patients with normal functional ovarian reserves produce a good number of oocytes at retrieval. However, in addition to quantity, oocyte maturity is an important variable for the success of reproductive technologies. In general, nearly 85% of retrieved oocytes are mature and reproductively useful, whereas the remaining percentage are still at metaphase I or germinal vesicle stage (MI: 4% and GV: 11 %, respectively). Due to the limited expectations held for in vitro maturation in said stimulated cycles, the rescue of immature oocytes is not widely used in current clinical practice and these oocytes are usually discarded due to the possibility of abnormal embryonic development or an increased rate of abortion.

The objective of our study is to assess if immature oocytes co-cultured with autologous cumulus cells is a safer strategy than just leaving the oocytes in standard culture.

Study Timeline

• Study First Submitted: 2019-02-27
• Study First Submitted QC: 2019-02-28
• Study First Posted: 2019-03-01
• Study Start: 2019-03-27
• Status Verified: 2019-07
• Primary Completion: 2019-07-30
• Study Completion: 2019-09-30
• Last Update Submitted: 2019-11-18
• Last Update Posted: 2019-11-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 60

Inclusion Criteria

• 18-35-year-old women
• BMI: >18 and < 30 kg/m2
• Normal female karyotype
• Normal uterus and ovaries at transvaginal ultrasound

Exclusion Criteria

• > 35 years
• PCO syndrome carriers
• Null follicle aspiration
• History of chemotherapy or radiotherapy

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Aneuploidy rate	The moment that the PB is extruded (between 1 hour and 50 hours after the denudation)	Aneuploidy rate of the PB

Trial Locations

Locations (1)

Ivi Barcelona; 🇪🇸 Barcelona, Spain