Body Composition Analysis and Time to Emergence From Remimazolam

• Conditions: Remimazolam; Body Composition
• Interventions: Device: body composition analysis

• Registration Number: NCT05512559
• Lead Sponsor: Samsung Medical Center

Brief Summary

Remimazolam is a novel general anesthetic drug. The time to emergence from remimazolam-based general anesthesia is variable among patients, but little is known about the risk factors for delayed emergence. We believe that information from body composition analysis may be helpful in understanding which patients are more likely to show delayed emergence from remimazolam.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2022-08-21
• Study First Submitted QC: 2022-08-21
• Study First Posted: 2022-08-23
• Study Start: 2022-09-05
• Primary Completion: 2022-12-30
• Status Verified: 2023-01
• Last Update Submitted: 2023-01-02
• Last Update Posted: 2023-01-04
• Study Completion: 2023-03

Recruitment & Eligibility

• Status: ENROLLING_BY_INVITATION
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

• Adult ASA I-III patients undergoing cerebral aneurysm coil embolization under general anesthesia using remimazolam

Exclusion Criteria

• Patients with preoperative mental change, hemodynamic instability, hemodialysis, heart failure, hypoalbuminemia, pregnancy

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
remimazolam	body composition analysis	general anesthesia induction with 6mg/kg/hr continuous infusion of remimazolam. general anesthesia maintenance with 1mg/kg/hr continuous infusion of remimazolam.

Primary Outcome Measures

Name	Time	Method
emergence time	at the time of emergence	relationship between body composition analysis information and time to emergence after discontinuing remimazolam infusion.

Secondary Outcome Measures

Name	Time	Method
time to loss of consciousness	at the time of induction	relationship between body composition analysis information and time to loss of consciousness after starting remimazolam infusion.
hypotension	from induction to emergence of anesthesia	relationship between body composition analysis information and hypotensive event during anesthesia

Trial Locations

Locations (1)

Samsung Medical Center, Sungkyunkwan University, School of Medicine; 🇰🇷 Seoul, Korea, Republic of