Single Versus Combined Antibiotic Therapy for Bacterial Peritonitis in Continuous Ambulatory Peritoneal Dialysis Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 300
- 试验地点
- 1
- 主要终点
- relapse or recurrent rate
研究概览
简要总结
To compare the efficacy of single versus combined antibiotic therapy for bacterial peritonitis in CAPD patients.
详细描述
To compare relapse and recurrent rate of peritonitis between single and combined antibiotic regimens for bacterial peritonitis in CAPD patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 15 Years 至 75 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age >/= 18 years old
- •ESRD patients on continuous ambulatory peritoneal dialysis more than 4 weeks
- •presence of symptom or sign of peritonitis
- •presence of WBC >100cell/mm3 with PMN >50% in peritoneal dialysate or gram stain positive for gram positive or gram negative bacteria
排除标准
- •presence of polymicrobial organism, non-fermentative gram negative organism, fungus, mycobacteria in peritoneal fluid or culture-negative
- •peritonitis from the organisms that required combined antibiotic therapy according to ISPD guideline 2010
- •hospital-acquired peritonitis
- •presence of catheter-related infection
- •history of peritonitis within 4 weeks
- •currently taking antibiotic
- •allergic to the antibiotic that used in the study(penicillin or cephalosporin or quinolone or aminoglycoside)
研究组 & 干预措施
cefazolin monotherapy
cefazolin IP for gram positive bacterial peritonitis
干预措施: cefazolin monotherapy (Drug)
ceftazidime+ciprofloxacin
2 synergistic antibiotics(ceftazidime IP and ciprofloxacin po for gram negative bacterial peritonitis)
干预措施: ceftazidime+ciprofloxacin (Drug)
ceftazidime monotherapy
ceftazidime IP for gram negative bacterial peritonitis
干预措施: ceftazidime monotherapy (Drug)
cefazolin+gentamicin
cefazolin IP and gentamicin IP for gram positive bacterial peritonitis
干预措施: cefazolin+gentamicin (Drug)
结局指标
主要结局
relapse or recurrent rate
时间窗: within 4 weeks after peritonitis treatment
次要结局
未报告次要终点