Single Versus Combined Antibiotic Therapy for Bacterial Peritonitis in CAPD Patients

Not Applicable

Completed

• Conditions: Peritonitis
• Interventions: Drug: cefazolin monotherapy; Drug: ceftazidime monotherapy; Drug: ceftazidime+ciprofloxacin; Drug: cefazolin+gentamicin

• Registration Number: NCT01785641
• Lead Sponsor: Chulalongkorn University

Brief Summary

To compare the efficacy of single versus combined antibiotic therapy for bacterial peritonitis in CAPD patients.

Detailed Description

To compare relapse and recurrent rate of peritonitis between single and combined antibiotic regimens for bacterial peritonitis in CAPD patients.

Study Timeline

• Study Start: 2012-12
• Study First Submitted: 2013-01-30
• Status Verified: 2013-02
• Study First Submitted QC: 2013-02-06
• Study First Posted: 2013-02-07
• Primary Completion: 2013-12
• Study Completion: 2013-12
• Last Update Submitted: 2024-02-20
• Last Update Posted: 2024-02-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

• age >/= 18 years old
• ESRD patients on continuous ambulatory peritoneal dialysis more than 4 weeks
• presence of symptom or sign of peritonitis
• presence of WBC >100cell/mm3 with PMN >50% in peritoneal dialysate or gram stain positive for gram positive or gram negative bacteria

Exclusion Criteria

• presence of polymicrobial organism, non-fermentative gram negative organism, fungus, mycobacteria in peritoneal fluid or culture-negative
• peritonitis from the organisms that required combined antibiotic therapy according to ISPD guideline 2010
• hospital-acquired peritonitis
• presence of catheter-related infection
• history of peritonitis within 4 weeks
• currently taking antibiotic
• allergic to the antibiotic that used in the study(penicillin or cephalosporin or quinolone or aminoglycoside)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
cefazolin monotherapy	cefazolin monotherapy	cefazolin IP for gram positive bacterial peritonitis
ceftazidime monotherapy	ceftazidime monotherapy	ceftazidime IP for gram negative bacterial peritonitis
ceftazidime+ciprofloxacin	ceftazidime+ciprofloxacin	2 synergistic antibiotics(ceftazidime IP and ciprofloxacin po for gram negative bacterial peritonitis)
cefazolin+gentamicin	cefazolin+gentamicin	cefazolin IP and gentamicin IP for gram positive bacterial peritonitis

Primary Outcome Measures

Name	Time	Method
relapse or recurrent rate	within 4 weeks after peritonitis treatment

Trial Locations

Locations (1)

Chulalongkorn university; 🇹🇭 Bangkok, Thailand