Bariatric Surgery and Skeletal Health
Completed
- Conditions
- Morbid Obesity
- Registration Number
- NCT01098942
- Lead Sponsor
- Massachusetts General Hospital
- Brief Summary
Bone loss may occur after bariatric (weight loss) surgery, but standard methods of measuring bone density in obese patients are potentially inaccurate. This study uses quantitative computed tomography to examine changes in bone mineral density after bariatric surgery. We are also studying mechanisms which may explain bone loss after bariatric surgery.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
- Either scheduled for Roux-en-Y Gastric Bypass surgery or enrolled in a lifestyle weight management program
Exclusion Criteria
- Weight ≥ than 450 lbs
- Postmenopausal women
- Significant heart, kidney, liver, or malignant disease
- Current disorders known to affect bone
- Use of medications known to affect bone for more than 7 days in the past 12 months
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Changes in bone mineral density by dual-energy x-ray absorptiometry (DXA) and quantitative computed tomography (QCT) 1 year
- Secondary Outcome Measures
Name Time Method Changes in serum and/or urine indices of bone formation and bone resorption, such as aminoterminal propeptide of type I collagen [PINP], osteocalcin, C-telopeptide cross-links [CTX]) 1 year Changes in bone microarchitecture by high-resolution peripheral quantitative computed tomography (HR-pQCT) 1 year
Trial Locations
- Locations (2)
MGH
🇺🇸Boston, Massachusetts, United States
Massachusetts General Hospital
🇺🇸Boston, Massachusetts, United States