A Prospective clinical study of innovative Wuqinxi exercise intervention in delaying the occurrence of freezing of gait in Parkinson's disease

Phase 1

Recruiting

• Conditions: Parkinson 's disease

• Registration Number: ITMCTR2000003767
• Lead Sponsor: Xinhua Hospital Affiliated to Shanghai Jiao Tong University, School of Medicine

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 20 February 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

1) Patients who were diagnosed with PD according to the 2015 international MDS PD criteria;
2) no history of FOG (NFOGQ score =0);
3) PD patients at high risk of developing FOG (the risk value was accounted according to our established predicting model for FOG);
4) having received a stable anti PD medication therapy for at least 2 months ;
5) aged ranging from 45 to 85 years old.

Exclusion Criteria

1) Patients were diagnosed with atypical parkinsonism, secondary parkinsonism or hereditary PD;
2) history of serous organic diseases (heart disease, hypertension, lung tuberculosis, nephritis, etc.);
3) history of serious arthritis, bone and joint diseases;
4) having regularly participated in sports exercises during the recent 2 months;
5) Mini Mental Stage Examination(MMSE) score was less than 23 points.

Study & Design

• Study Type: Interventional study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
the incidence of freezing of gait;the difference value between Apathy scale score at baseline and AS score after intervention;

Secondary Outcome Measures

Name	Time	Method
the difference value between MDS-UPDRS III score at baseline and the MDS-III score after intervention;the difference of the Bold signal of activated brain areas at baseline and after intervention;the difference value between HAMD score at baseline and HAMA score after intervention;the difference value between the gait parameters at baseline and the gait parameters after intervention;the difference value between PDQ-39 score at baseline and PDQ-39 score after intervention;the difference value between FAB score at baseline and FAB score after intervention;the difference value between CGI score at baseline and CGI score after intervention;the difference value between HAMA score at baseline and HAMA score after intervention;