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A Comparison of 882C87 Versus Acyclovir in the Treatment of Herpes Zoster in Patients With Weakened Immune Systems

Phase 3
Completed
Conditions
HIV Infections
Chickenpox
Registration Number
NCT00002315
Lead Sponsor
Glaxo Wellcome
Brief Summary

To determine the efficacy of oral 882C87 compared with oral acyclovir in the treatment of localized herpes zoster in immunocompromised patients. To assess the safety and tolerance of oral 882C87 in immunocompromised patients.

Detailed Description

Patients are randomized to receive either 882C87 or acyclovir with corresponding placebos for 14 days, with two hundred patients in each of the two groups. They are stratified by presence or absence of HIV infection. Patients undergo 6 months of follow-up.

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
400
Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

Study Type
INTERVENTIONAL
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
Secondary Outcome Measures
NameTimeMethod

Trial Locations

Locations (25)

Cedars Sinai Med Ctr

🇺🇸

Los Angeles, California, United States

N Texas Ctr for AIDS & Clin Rsch

🇺🇸

Dallas, Texas, United States

Univ TX Med Branch

🇺🇸

Nassau Bay, Texas, United States

Washington Univ

🇺🇸

St. Louis, Missouri, United States

Simon - Williamson Clinic

🇺🇸

Birmingham, Alabama, United States

Silver Lake Med Inc

🇺🇸

Providence, Rhode Island, United States

Saint Francis Mem Hosp

🇺🇸

San Francisco, California, United States

AIDS Community Research Consortium

🇺🇸

Redwood City, California, United States

SORRA / NC Research Ctr

🇺🇸

Birmingham, Alabama, United States

Sunnyvale Med Clinic

🇺🇸

Sunnyvale, California, United States

Roger Williams Med Ctr

🇺🇸

Providence, Rhode Island, United States

Med Associates Clinic

🇺🇸

Dubuque, Iowa, United States

New Mexico Med Group

🇺🇸

Albuquerque, New Mexico, United States

Clinical Research Consultants

🇺🇸

Trumbull, Connecticut, United States

Oschner Clinic

🇺🇸

New Orleans, Louisiana, United States

Infections Ltd / Physicians Med Ctr

🇺🇸

Tacoma, Washington, United States

Med Consultants LTD

🇺🇸

Milwaukee, Wisconsin, United States

MacGregor Med Association

🇺🇸

Houston, Texas, United States

Univ of Arizona / Univ Med Ctr

🇺🇸

Tucson, Arizona, United States

Hanover Med Specialists

🇺🇸

Wilmington, North Carolina, United States

Oregon Health Sciences Univ

🇺🇸

Portland, Oregon, United States

Jordon Diagnostics and Research Inc

🇺🇸

High Point, North Carolina, United States

Vanderbilt Med Ctr

🇺🇸

Nashville, Tennessee, United States

Oregon Research Group

🇺🇸

Eugene, Oregon, United States

Rhinelander Med Ctr

🇺🇸

Rhinelander, Wisconsin, United States

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