Parasternal Intercostal Muscle Thickening as an Additive Weaning Criterion to Minimize Re-intubation Rate: a Randomized Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Incidence of reintubation
研究概览
简要总结
Increased days of MV are not without hazards, including barotraumas and ventilator-associated pneumonia. Similarly, premature separation of MV is associated with increased mortality secondary to adverse cardiorespiratory events. Therefore, the time of weaning should be wisely evaluated. There is growing evidence concerning respiratory muscles dysfunction that contributes to difficulty or prolonged liberation from MV.
详细描述
Researchers aim to evaluate the influence of adding parasternal thickening fraction to the standard weaning criteria and its impact on reintubation
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •critically ill patient mechanically ventilated for 24 hours or more first spontaneous breathing trial
排除标准
- •patient refusal difficult ultrasound views tracheostomized patient neuromuscular disorders
研究组 & 干预措施
Control group
patients in control will be weaning using standard criteria
干预措施: Sham parasternal intercostal thickening (Device)
Ultrasound
patient in this group will be weaned using standard criteria plus mean parasternal thickening fraction less than 6.5 %
干预措施: Parasternal intercostal thickening fraction (Device)
结局指标
主要结局
Incidence of reintubation
时间窗: Within 72 hours after extubation
need for reintubation
次要结局
- Incidence of weaning failure(within 72 hours post-extubation)
研究者
Mina Adolf Helmy
Lecturer of anesthesia and critical care
Cairo University