Impact of PD1-lymphocytes in Bronchoalveolar Lavage of Patients With Lung Cancer

• Conditions: Lung Cancer
• Interventions: Diagnostic Test: bronchoalveolar lavage

• Registration Number: NCT04827667
• Lead Sponsor: University of Vienna

Brief Summary

The aim of this trial is to assess PD1-lymphocytes in bronchoalveolar lavage in patients with lung cancer, ILD and asthma.

Detailed Description

In this trial, 20 patients with lung cancer, 10 patients with asthma and 10 patients with interstitial lung disease who have to undergo bronchocospy for medical reasons are enrolled. In each patient, bronchoalveolar lavage is performed to assess PD1-lymphocytes.

Study Timeline

• Study Start: 2021-03-18
• Study First Submitted: 2021-03-29
• Study First Submitted QC: 2021-03-29
• Status Verified: 2021-04
• Study First Posted: 2021-04-01
• Last Update Submitted: 2021-04-04
• Last Update Posted: 2021-04-06
• Primary Completion: 2021-09-30
• Study Completion: 2021-12-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• age >18 years
• patients with lung cancer, asthma or ILD and indication for bronchoscopy for medical reasons
• Ability to provide informed consent

Exclusion Criteria

• acute excacerbation in patients with asthma or ILD
• endoluminal tumor growth or penumonia in patients with lung cancer

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Patients with asthma	bronchoalveolar lavage	In patients with asthma with indication for bronchoscopy, bronchoalveolar lavage is performed to assess PD1-lymphocytes.
Patients with lung cancer	bronchoalveolar lavage	In lung cancer patients with indication for bronchoscopy, bronchoalveolar lavage is performed to assess PD1-lymphocytes.
Patients wiht interstitial lung disease	bronchoalveolar lavage	In patients with interstitial lung disease with indication for bronchoscopy, bronchoalveolar lavage is performed to assess PD1-lymphocytes.

Primary Outcome Measures

Name	Time	Method
To assess and compare PD1-lmyphocytes in bronchoalveolar lavage in patients with malignant and benign lung diseases to evluate their impact in lung cancer patients	6 months

Trial Locations

Locations (1)

Medical University of Vienna; 🇦🇹 Vienna, Austria