Effect of Tacrolimus on Dry Eye Syndrome Related to Chronic Graft-Versus-Host Disease.
Not Applicable
- Conditions
- Dry eye related to chronic GVHD
- Registration Number
- JPRN-UMIN000011479
- Lead Sponsor
- Keio University School of Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 20
Inclusion Criteria
Not provided
Exclusion Criteria
1, Patients with Sjogren's syndrome, ocular pemphigoid, and Stevens-Johnson syndrome 2, Patients with a history of ophthalmic surgery 3, Patients wearing contact lens 4, Patients who will be applied radiation treatment during the study 5, Patients dosed cevimeline hydrochloride hydrate and /or pilocarpine(eye drop or oral drug) 6, Patients having a concern of becoming severe dry eye because of having GVHD in other organs and so on
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Anterior ocular segment remark Corneal sensitivity Schirmer's test Tear film breakup time Fluorescein staining Rose-bengal staining Subjective symptom
- Secondary Outcome Measures
Name Time Method Cytotechnology(IC, BC) Biopsy Non-contact infrared meibography Laser confocal microscopy