Role of Aortic Valve Composition in Pathophysiology and Diagnosis of Aortic Stenosis
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 55
- 试验地点
- 2
- 主要终点
- Aortic valve tissue composition measured from pre-procedural computed tomography angiography
研究概览
简要总结
The study aims to evaluate composition differences of aortic valves in different stages and phenotypes of aortic stenosis using non-invasive imaging and histology.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •aortic valve replacement or heart transplant as part of standard care decided by the local Heart Team
- •pre-surgical computed tomography angiography
- •informed consent
排除标准
- 未提供
结局指标
主要结局
Aortic valve tissue composition measured from pre-procedural computed tomography angiography
时间窗: up to 30-days before surgery
Quantitative analysis of aortic valve composition will be based on pre-surgical planning CTA images using semi-automated software (Autoplaque version 2.5, Cedars-Sinai Medical Center, Los Angeles, CA, USA) for calcified, non-calcified and total tissue volumes.
Aortic valve tissue composition measured from quantitative histology
时间窗: immediately post-surgery
Different stains will be used to characterize composition of excised aortic valves (hematoxylin and eosin, Movat Pentachrome, Van Gieson's trichrome, Congo Red, anti-CD68 antibody
次要结局
未报告次要终点
研究者
Kajetan Grodecki
Principal Investigator
Medical University of Warsaw