Decision Making, Daily Experiences, and Brain Activity in Young Adult Women

Not Applicable

Recruiting

• Conditions: Binge-Eating Disorder
• Interventions: Behavioral: Speaking Activity; Behavioral: Talking Activity

• Registration Number: NCT04125589
• Lead Sponsor: Mclean Hospital

Brief Summary

The investigators are doing a study of women with and without binge-eating disorder to learn more about what happens when people engage in everyday decision-making activities. The investigators are interested in learning more about brain activity during everyday decision-making and how everyday decision-making relates to a variety of daily experiences. Examples of everyday decisions include deciding which product to buy, deciding what to eat for a snack, and deciding how to spend free time.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2019-09-27
• Study First Submitted QC: 2019-10-10
• Study First Posted: 2019-10-14
• Study Start: 2019-12-31
• Status Verified: 2023-10
• Last Update Submitted: 2023-10-17
• Last Update Posted: 2023-10-18
• Primary Completion: 2024-07
• Study Completion: 2024-07

Recruitment & Eligibility

• Status: RECRUITING
• Sex: Female
• Target Recruitment: 80

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Speaking Activity and Talking Activity	Speaking Activity	Participants will engage in a speaking activity first and a talking activity second.
Speaking Activity and Talking Activity	Talking Activity	Participants will engage in a speaking activity first and a talking activity second.
Talking Activity and Speaking Activity	Speaking Activity	Participants will engage in a talking activity first and a speaking activity second.
Talking Activity and Speaking Activity	Talking Activity	Participants will engage in a talking activity first and a speaking activity second.

Primary Outcome Measures

Name	Time	Method
Decision-making behavior (actual decisions)	Up to 1 hour post-intervention	Decisions (i.e., percent of goal-inconsistent decisions from challenge trials)
Decision-related BOLD activation (reward regions-of-interest)	Up to 1 hour post-intervention	Percent change in blood oxygen level-dependent (BOLD) signal in response to decision making in regions involved in reward (e.g., nucleus accumbens, insula)
Decision-related BOLD activation (executive function regions-of-interest)	Up to 1 hour post-intervention	Percent change in blood oxygen level-dependent (BOLD) signal in response to decision making in regions involved in executive function (e.g., dorsolateral prefrontal cortex, inferior frontal gyrus)

Trial Locations

Locations (1)

McLean Hospital; 🇺🇸 Belmont, Massachusetts, United States