Comparison of the effect of peri-articular injection of dextrose and corticosteroid with dextrose alone on pain relief in patients with knee osteoarthritis.

Phase 3

Recruiting

• Conditions: Osteoarthritis.; Primary osteoarthritis, unspecified site; M19.91

• Registration Number: IRCT20210930052641N1
• Lead Sponsor: Sanandaj University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 7 February 2022

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Existence of at least three of the six ACR criteria: 1. Age over 50 years, 2. Morning stiffness less than 30 minutes, 3. Cryptation sensation in active knee movements, 4. Bone sensitivity, 5. Bone enlargement, 6. Absence of warmness at the touch of the joint
Evidence for osteoarthritis on knees radiography
Grade 2 or 3 osteoarthritis based on the Kellgren-Lawrence index

Exclusion Criteria

Previous therapeutic injection with dextrose
Use of braces or NSAIDs or daily use of opioids during the study
Pregnancy, Lactation
Contraindication to corticosteroid injection
History of metabolic bone disease, coagulation disorders
Injection of steroid drugs in the last 2 months
History of joint fracture
History of inflammatory joint disease, post-infection arthritis, joint dysplasia, congenital anomalies, crystallopathy, post-traumatic arthritis, malignancy, vascular necrosis
Obesity BMI>30
Knee infection in the last three months or knee inflammation
Candidate patients for knee surgery
Diabetes

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Pain. Timepoint: Before intervention , 1 month after one intervention and 3 months after one intervention. Method of measurement: using questionnaire (Western Ontario & McMaster Universities Osteoarthritis Index ).;Knee fatigue. Timepoint: Before intervention , 1 month after one intervention and 3 months after one intervention. Method of measurement: using questionnaire (Western Ontario & McMaster Universities Osteoarthritis Index ).;Physical function. Timepoint: Before intervention , 1 month after one intervention and 3 months after one intervention. Method of measurement: using questionnaire (Western Ontario & McMaster Universities Osteoarthritis Index ).