Autonomic Nervous Activity in Women With Gestational Diabetes
- Conditions
- Gestational Diabetes
- Registration Number
- NCT00867022
- Lead Sponsor
- University of Helsinki
- Brief Summary
Through complex hormonal pathways, insulin resistance can lead to the activation of the sympathetic nervous system, and vice versa. Schobel et al. showed that in PE patients, mus-cle sympathetic nerve activity (MSNA) is increased compared with normotensive pregnant and non-pregnant women. Studies assessing heart-rate variability and plasma noradrenalin concentrations also suggest increased sympathetic activity in PE. It has been hypothesized that sympathetic over-activity is a precursor of PE, normally compensated for by vasodilating mechanisms, but resulting in PE when the mechanisms fail. In addition to sympathetic activity, various markers of inflamma-tion are also associated with reduced insulin sensitivity, suggesting that chronic sub-clinical inflamma-tion could be part of the insulin resistance syndrome. The role of sympathetic over-activity and inflammatory markers in gestational diabetes has not been investigated
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 80
- Clinical diagnosis of gestational diabetes (OGTT) with or without BP > 140/90.
- Pregnant control with normal OGTT-
- Smoking
- Uncontrolled hypertension
- Diabetes
- Medication affecting sympathetic activity
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Serum Noradrenalin level
- Secondary Outcome Measures
Name Time Method Heart rate variability: LF, VLF, HF
Trial Locations
- Locations (1)
Department of Obstet and Gyn, Helsinki University Hospital
🇫🇮Helsinki, Uusimaa, Finland