Efficacy of Preoperative Intravenous Dexamethasone in Primary Total Knee Arthroplasty
- Registration Number
- NCT02102815
- Lead Sponsor
- Thammasat University
- Brief Summary
To determine efficacy of preoperative IV dexamethasone for postoperative pain control after TKA.
- Detailed Description
Preoperative intravenous over 0.1 mg/kg of dexamethasone could be reduced pain after primary TKA.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
- Osteoarthritis of the knee who undergoing unilateral primary total knee arthroplasty
- 50-85 years old
- ASA class 1-3
Exclusion Criteria
- Unable to perform spinal anaesthesia
- History of drug allergies: steroids
- Renal impairment (CrCl <30 mL/min)
- Liver impairment
- Cognitive function disorders
- Poor controlled DM (HA1C > 7.5)
- Morning DTX at operative day > 180 mg%
- Received corticosteroids within 3 months before surgery
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Placebo Normal saline Preoperative intravenous normal saline 50 mL slowly push over 5 minutes Dexamethasone Dexamethasone Preoperative dexamethasone 0.15mg/Kg mixed with NSS to 50 mL IV slowly push over 5 minutes
- Primary Outcome Measures
Name Time Method post-operative pain 48 hours measured with VAS for pain, drugs for relief pain
- Secondary Outcome Measures
Name Time Method Functional knee score 3 month measured with WOMAC, KSS
post-operative nausea and vomiting 48 hours measured with amount of nausea/vomiting and drugs requiring for fixed its.
complication of preoperative dexamethasone 2 weeks measured with wound complication, blood sugar level
inflammatory level 48 hours CRP level
Trial Locations
- Locations (1)
Orthopaedic department, Faculty of medicine, Thammasat university
🇹ðŸ‡Klongluang, Pathumthani, Thailand