Fluid restriction versus 0.9% saline infusion in the treatment of hyponatraemia due to the syndrome of inappropriate antidiuresis in patients with pneumonia

Not Applicable

• Conditions: Syndrome of inappropriate antidiuresis secondary to pneumonia; Respiratory

• Registration Number: ISRCTN89527210
• Lead Sponsor: Beaumont Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2018-01-29
• Last Update Posted: 13 July 2020
• Study Completion: 2020-10-01

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

1. Age > 18 years
2. Eu-volemic
3. New asymptomatic hyponatraemia with plasma sodium 120 - 130 mmol/L
4. Biochemical confirmation of SIAD, including exclusion of adrenal insufficiency and hypothyroidism.
5. Radiographic confirmation of pneumonia
6. Clinical confirmation of pneumonia
7. Systolic blood pressure > 100 mmHg

Exclusion Criteria

1. Symptomatic or severe hyponatraemia (plasma sodium < 120 mmol/L)
2. Volume depletion / hypovolaemia / systolic BP < 100 mmHg
3. CCF
4. Uncontrolled hyperglycemia
5. AKI
6. Diuretic therapy
7. Clinical imperative for intravenous fluids
8. Chronic hyponatraemia

Study & Design

• Study Type: Interventional
• Study Design: Not specified