Effects of dexmedetomidine vs magnesium sulphate on intraoperative blood pressure and heart rate changes in adult patients undergoing maxillectomy and mandibulectomy operatio
Phase 4
- Conditions
- Health Condition 1: C060- Malignant neoplasm of cheek mucosaHealth Condition 2: C050- Malignant neoplasm of hard palateHealth Condition 3: C062- Malignant neoplasm of retromolar area
- Registration Number
- CTRI/2023/01/049060
- Lead Sponsor
- il
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1.ASA 1 and 2
2.patients undergoing elective mandibulectomy or maxillectomy surgery
Exclusion Criteria
1.patient refusal
2.history of allergy to study drug
3.patients on calcium channel blockers, beta blockers,ACE inhibitors, anticoagulant
4.h/o CVA,IHD,COPD
5.impaired renal function test, impaired liver function test.
6.preop HR of less than 45/min, second or third degree heart block
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Effects of study drugs on Hemodynamic parameters like blood pressure and heart rate <br/ ><br>IntraoperativelyTimepoint: 1.baseline <br/ ><br>2.before induction (after bolus) <br/ ><br>3.15mins after induction <br/ ><br>4.30mins after induction <br/ ><br>5. 45mins after induction <br/ ><br>6.60mins after induction <br/ ><br>7.90mins after induction <br/ ><br>8.120mins after induction <br/ ><br>9.150mins after induction <br/ ><br>10.180mims after induction <br/ ><br>11.210mins after induction <br/ ><br>12.240mins after induction
- Secondary Outcome Measures
Name Time Method 1.adverse effects of study drugs <br/ ><br>2.postoperative sedation assessment using Ramsay sedation scoreTimepoint: 1.5mins before extubation <br/ ><br>2.5mins in PACU <br/ ><br>3.10mins in PACU <br/ ><br>4.15mins in PACU <br/ ><br>5.30mins in PACU <br/ ><br>6.60mins in PACU <br/ ><br>7.90mins in PACU <br/ ><br>8.120mins in PACU <br/ ><br>9.150mins in PACU <br/ ><br>10.180mins in PACU <br/ ><br>11.210mins in PACU <br/ ><br>12.240mins in PAC