Strength Training and ADLs in Childhood Leukemia and Lymphoma Patients
- Conditions
- Childhood Cancer
- Interventions
- Other: Exercise
- Registration Number
- NCT03934060
- Lead Sponsor
- Technical University of Munich
- Brief Summary
Reduced activity levels and reduced muscular strength could severely impair the activities of daily living (ADLs) in pediatric leukemia and Non-Hodgkin lymphoma patients. Increased muscle strength is associated with improved accomplishment of ADLs and consequently greatest possible normality, autonomy and mobility. Primary outcome of this RCT (n=20/20) is the analysis of effects of a treatment-associated and close to every day life strength training (2-3 times/week) compared to a general exercise program (standard care).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 40
- Diagnosed with Acute Leukemia or Non-Hodgkin Lymphoma
- Diagnosed and/or treated at the Kinderklinik München Schwabing, Technische Universität München
- Informed consent as documented by signature
- Medical contraindications regarding strength training (e.g. risk of bleeding, ...)
- Contraindications to one of the inclusion criteria mentioned above
- Inability to follow the procedures and understand the intervention and assessments of this study, e.g. due to cognitive impairment, language problems, psychological disorders etc.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Intervention Exercise Supervised exercise training including specific strength training tools and general exercise contents (standard care), 2-3 times per week, 30 minutes per session
- Primary Outcome Measures
Name Time Method Change of score of the Activities Scale for Kids - performance version Change of the ASK score from baseline to 3 months, change from 3 months to 6 months, change from 6 months to 12 months The ASK - Activities Scale for Kids performance version by NL Young assesses an overall summary score (0-100) of self-reported activities of daily living in children and adolescents. The scale monitors changes associated with therapeutic interventions. Higher values represent a better outcome. The ASK contains 30 items in 7 sub-domains (personal care, dressing, other skills, locomotion, play, standing skills and transfer).
- Secondary Outcome Measures
Name Time Method Change of motor performance analyzed with the Motor performance test in Pediatiric Oncology (MOON) Change of motor performance from baseline to 6 months Motor performance is assessed by the MOON-test, a tool to examine motor performance abilities in children and adolescents during and after cancer treatment. There's no summary score; reference values of healthy children enable comparison of the tested children.
Change of level of physical activity Change of physical activity level from baseline to 3 months, from 3 to 6 months, from 6 to 12 months Physical activity is assessed using an accelerometer (movisens) for the period of 7 days.
Change in performance in a parkour in activities of daily living Change of score in the parkour from baseline to 6 months A standardized parkour with tasks imitating activities of daily living is used to objectively verify the ASK score. Points from 0-4 are counted for each task depending on quality of movement (0 = task can not be completed, 1 = task can be completed with help, 2 = task can be completed with several attempts, 3 = task can be completed with only little effort, 4 = task can be completed without any problems or effort). There are no reference values for the parkour, but intra-individual changes are analyzed.
Trial Locations
- Locations (1)
Kinderklinik München Schwabing TUM School of Medicine, Department of Pediatrics and Children's Cancer Research Center, Technical University of Munich
🇩🇪Munich, Bavaria, Germany