Caffeine for Preterm Infants With Apnea of Prematurity(AOP)

Not Applicable

• Conditions: Apnea of Prematurity; Caffeine
• Interventions: Drug: 20mg/kg of caffeine; Drug: 80mg/kg of caffeine

• Registration Number: NCT03298347
• Lead Sponsor: Daping Hospital and the Research Institute of Surgery of the Third Military Medical University

Brief Summary

Nowadays,caffein is commonly used for AOP, and it reduces the intubation rate in preterm infants. However, intubation is needed in about 20%-50% of partial neonates. How to reduce the intubation rate effectively is a challenge for neonatologists.

Detailed Description

Less evidences about more dose of caffein used in preterm infants.

Study Timeline

• Status Verified: 2017-09
• Study First Submitted: 2017-09-27
• Study First Submitted QC: 2017-09-27
• Last Update Submitted: 2017-09-27
• Study Start: 2017-10-01
• Study First Posted: 2017-10-02
• Last Update Posted: 2017-10-02
• Primary Completion: 2018-10-01
• Study Completion: 2018-10-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• gestational age less than 32 weeks;
• appear AOP;
• parents'consents are obtained.

Exclusion Criteria

• major congenital abnormalities;
• Parents' rejection

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
20mg/kg of caffeine	20mg/kg of caffeine	20mg/kg of caffeine is given to treat AOP.
80mg/kg of caffeine	80mg/kg of caffeine	80mg/kg of caffeine is given to treat AOP.

Primary Outcome Measures

Name	Time	Method
the rate of AOP	within 100 days	AOP appears again in preterm infants

Trial Locations

Locations (1)

Daping Hospital and the Research Institute of Surgery of the Third Military Medical University; 🇨🇳 Chongqing, Chongqing, China