Preemptive Analgesia in Children Using Caudal Epidural Ropivacaine: A Prospective, Randomized, Double-blinded, Controlled Study
Overview
- Phase
- Not Applicable
- Intervention
- Ropivacaine
- Conditions
- Inguinal Herniorrhaphy
- Sponsor
- Loma Linda University
- Enrollment
- 26
- Locations
- 1
- Primary Endpoint
- Usage of Pain Medications
- Status
- Terminated
- Last Updated
- 7 years ago
Overview
Brief Summary
Caudal epidural analgesia (caudal block) is used in standard pediatric anesthesia practice. It has been shown to be effective in managing postoperative pain in children undergoing abdominal and infraumbilical surgery (Tobias et al 1994). Furthermore, studies have shown that children receiving caudal blocks have secondary benefits such as lower narcotic and anesthetic requirements, more rapid awakening from general anesthesia, decreased time to discharge home, and fewer pain-related behaviors postoperatively (Conroy et al 1993, Tobias et al 1995, Tobias 1996).
This proposed study involves the use of a caudal block in children undergoing elective inguinal herniorrhaphy or orchiopexy to evaluate the role of preemptive analgesia in pediatric pain management. We hypothesize that by inhibiting peripheral pain receptors with a caudal block before the onset of a painful stimulus, we can decrease central nervous system sensitization and reduce postoperative analgesic requirements.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Age 2 years or younger.
- •Weight 33 kg or less.
- •Scheduled for elective inguinal herniorrhaphy or orchiopexy.
- •American Society of Anesthesiologists Class 1, 2 or 3.
Exclusion Criteria
- •Age over 2 years.
- •Weight over 33 kg.
- •Allergy to ropivacaine.
- •Usual contraindications to caudal anesthesia (patient refusal, skeletal or spinal cord anomaly, coagulopathy, infection at insertion site, ongoing bacteremia)
Arms & Interventions
Group CB
Subjects in this arm will receive caudal ropivacaine 0.25% at a dose of 1ml/kg (maximum 15ml) with 1:200,000 epinephrine after induction of general anesthesia prior to surgical incision.
Intervention: Ropivacaine
Group CA
Group CA (Caudal After-control group) will receive caudal ropivacaine 0.25% at a dose of 1ml/kg (maximum 15ml) with 1:200,000 epinephrine after completion of surgery but before emergence from anesthesia.
Intervention: Ropivacaine
Group LIA
Group LIA (Local Infiltration After-control group) will receive local infiltration of ropivacaine 0.25% up to 1ml/kg (maximum 15ml) around the surgery site at the conclusion of surgery but before emergence from anesthesia.
Intervention: Ropivacaine
Outcomes
Primary Outcomes
Usage of Pain Medications
Time Frame: Over 24 hours