Dynamic Change of Doppler-based Renal Resistive Index in Predicting Renal Recovery

Completed

• Conditions: Acute Kidney Injury
• Interventions: Diagnostic Test: Doppler-based renal resistive index

• Registration Number: NCT05866250
• Lead Sponsor: The First Hospital of Jilin University

Brief Summary

The goal of this observational study is to observe the correlation between dynamic changes in the Doppler-based renal resistive index (RI) and the occurrence of persistent acute kidney injury (AKI) in critically ill patients. The main questions it aims to answer are:

* Are dynamic changes of RI within 24 or 48 hours associated with the prognosis of AKI (NO AKI, transient AKI, persistent AKI)?

* what are the influencing factors of changes in RI? Participants will measure values of RI in patients at admission (0 hour), after 24 hours and after 48 hours, respectively, and collect characters such as age, sex, vital signs, Apache II, diagnosis, renal function, applied drugs, fluid, 72-hour renal function and renal replacement, followed renal replacement and the mortality rate at 28 days.

Detailed Description

NO AKI is defined as No AKI occurred within 72 hour after ICU admission; Transient AKI is defined as AKI with recovery, which refers to the reduction in AKI stage ( (i.e., a decrease of serum creatinine, reversal of oliguria without diuretic therapy, and without need for renal replacement therapy) occurring with 72 hour after ICU admission; Persistent AKI is defined as AKI without recovery occurring with 72 hour after ICU admission.

Study Timeline

• Study First Submitted: 2023-05-10
• Study First Submitted QC: 2023-05-10
• Study First Posted: 2023-05-19
• Study Start: 2023-08-01
• Primary Completion: 2023-12-30
• Study Completion: 2024-03-01
• Status Verified: 2024-05
• Last Update Submitted: 2024-05-14
• Last Update Posted: 2024-05-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 467

Inclusion Criteria

• Patients admitted to the ICU within 24 h of admission.

Exclusion Criteria

• Chronic kidney disease stage III-V;
• History of kidney transplantation;
• Previously known renal artery stenosis or renal vein thrombosis；
• Cardiac arrhythmia precluding renal Doppler measurement;
• Expected hospital stay < 72 h；
• Pregnant patients
• Last, patients with hospital stays < 72 h, since they could not be classified as having transient or persistent AKI according to our definitions, were secondarily excluded.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
critically ill patients	Doppler-based renal resistive index	All newly admitted ICU patients

Primary Outcome Measures

Name	Time	Method
The prognosis of AKI	72 hours	NO AKI, transient AKI, persistent AKI. Transient AKI refers to the reduction in AKI stage ( (a decrease of serum creatinine, reversal of oliguria without diuretic therapy, and without need for renal replacement therapy) occurring with 72 hour after ICU admission. Persistent AKI refers to AKI without recovery occurring within 72 hours after ICU admission.

Secondary Outcome Measures

Name	Time	Method
Recovery of kidney function	28 days	A decrease of serum creatinine, reversal of oliguria without diuretic therapy, and without need for renal replacement therapy.
Mortality	28 days	Death or suivival

Trial Locations

Locations (7)

Jilin Province People's Hospital; 🇨🇳 Changchun, Jlin, China

The Third Affiliated Hospital of Changchung University; 🇨🇳 Changchun, Jlin, China

Dunhua City Hospital; 🇨🇳 Dunhua, Jlin, China

Jilin Central Hospital; 🇨🇳 Jilin, Jlin, China

Meihekou Central Hospital; 🇨🇳 Meihekou, Jlin, China

The First Hospital of Jilin University; 🇨🇳 Changchun, Jlin, China

Jilin Siping Central People's Hospital; 🇨🇳 Siping, Jlin, China