Comparison of the effect of platelet-rich plasma injection activated by light radiation with platelet-rich plasma injection in the treatment of arthritis

Phase 3

Conditions: Knee osteoarthritis.
Osteoarthritis of knee

Registration Number: IRCT20140907019073N7

Lead Sponsor: Iran University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: All

Target Recruitment: 40

Inclusion Criteria

Having primary knee osteoarthritis grade 2 and 3 according to the doctor's diagnosis and based on the Kellgren and Lawrence criteria (the presence of knee pain, morning dryness for less than 30 minutes, crypts during movement and radiological signs of osteoarthritis including joint space reduction, subchondral bone sclerosis and osteophyte formation in the knee )
Age 50-75 years
Having persistent knee pain for at least six months with a severity of at least 4 based on the VAS scale in activities such as going up and down the stairs, sitting for a long time and squatting
Ability to walk independently for at least 30 meters
Body mass index equal to or less than 35
Complete consent of the patient to participate in the research
Balanced mental state

Exclusion Criteria

History of intra-articular injections in the knee during the last six months
Having neuromuscular diseases
Presence of acute traumatic injury in other ligaments and structures of the knee joint as confirmed by a specialist doctor
History of previous surgery or injury in the knee and other joints of the lower limbs during the last year
Presence of bone implants
The presence of new fractures in the lower limbs during the last year
Getting malignant tumors
Participation in sports therapy and physiotherapy programs during the last three months

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Feeling knee pain by Visual Analogue Scale (VAS). Timepoint: The time of follow-up of patients is zero months (first visit), one and six months. Method of measurement: with the VAS questionnaire.;Knee function with WOMAC(Western Ontario and McMaster Universities Osteoarthritis Index) scale. Timepoint: The time of follow-up of patients is zero months (first visit), one and six months. Method of measurement: with WOMAC questionnaire.

Secondary Outcome Measures

Name	Time	Method
Knee range of motion. Timepoint: The time of examination of patients is in zero months (initial visit), one and six months. Method of measurement: Goniometry.;Timed Up & Go test: The ability of a person to get up from a chair over a distance of 3 meters and return to the chair. Timepoint: The time of examination of patients is in zero months (initial visit), one and six months. Method of measurement: Stopwatch (seconds).;Six Minute Walk test: The person's ability to walk for 6 minutes. Timepoint: The time of examination of patients is in zero months (initial visit), one and six months. Method of measurement: Distance measurement (meter).;Stair climbing test: The ability of a person to climb stairs to reach the stage of pain or fatigue. Timepoint: The time of examination of patients is in zero months (initial visit), one and six months. Method of measurement: The number of steps taken.