Comparison of the efficacy of platelet-enriched plasma injection and laser on knee arthrosis

Phase 3

Recruiting

Conditions: Knee Osteoarthritis.
Osteoarthritis of knee

Registration Number: IRCT20140907019073N6

Lead Sponsor: Iran University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 60

Inclusion Criteria

Grade 2 and 3 of primary knee osteoarthritis acording to KL criteria
Age 50-75 year
Persistent knee pain for at least 6 months with intensity more than 4 according to VAS in activity such as going up and down stair, long period of sitting and squatting
Ability to walk independently for more than 30 m.
BMI below 35 kg/m2
The patient has full consent to participate in the research.
The patient should have a balanced mental state.

Exclusion Criteria

The patient has a history of intra-articular injection in the knee during the last six months.
The patient has neuromuscular diseases.
The patient has a history of acute traumatic injury to other ligaments and structures of the knee joint with the approval of a specialist.
The patient has a history of surgery or previous injury in the knee and other lower limb joints over the last year.
The patient has bone implants.
The patient has a new fracture in the lower extremities during the last year.
The patient has malignant tumors.
The patient has participated in exercise therapy and physiotherapy programs during the last three months.

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Knee function with WOMAC(Western Ontario and McMaster Universities Osteoarthritis Index) scale. Timepoint: Before the intervention and one month and three months after the intervention. Method of measurement: Western Ontario and McMaster Universities Osteoarthritis Index questionnaire.;Feeling knee pain by Visual Analogue Scale (VAS). Timepoint: Before the intervention and one month and three months after the intervention. Method of measurement: Visual Analogue Scale (VAS).

Secondary Outcome Measures

Name	Time	Method
Knee range of motion. Timepoint: Before the intervention, one month and three months after the intervention. Method of measurement: Goniometry.;Timed Up & Go test: The ability of a person to get up from a chair over a distance of 3 meters and return to the chair. Timepoint: Before the intervention, one month and three months after the intervention. Method of measurement: Stopwatch (seconds).;Six Minute Walk test: The person's ability to walk for 6 minutes. Timepoint: Before the intervention, one month and three months after the intervention. Method of measurement: Distance measurement (meter).;Stair climbing test: The ability of a person to climb stairs to reach the stage of pain or fatigue. Timepoint: Before the intervention, one month and three months after the intervention. Method of measurement: The number of steps taken.