Comparison of Dietary Fats on Vascular Parameters

Not Applicable

• Conditions: Healthy

• Registration Number: NCT01876394
• Lead Sponsor: Unity Health Toronto

Brief Summary

The purpose of the study is to examine the effect of consuming 50g of fat from 5 different sources (coconut, canola, grapeseed, chia, and butter) on arterial stiffness, blood pressure and blood glucose levels. It is hypothesized that butter will have the most detrimental effect on acute vascular function. Canola, grapeseed and chia oil with their decreased content of SFA are hypothesized to impair vascular function to a lesser extent.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2013-06-09
• Study First Submitted QC: 2013-06-09
• Study First Posted: 2013-06-12
• Study Start: 2014-06
• Status Verified: 2016-03
• Last Update Submitted: 2016-03-09
• Last Update Posted: 2016-03-10
• Primary Completion: 2016-04
• Study Completion: 2016-06

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

• Healthy
• Age 18-65 years
• BMI < 30 kg/m2
• Brachial systolic blood pressure ≤ 140 mmHg
• Brachial diastolic blood pressure ≤ 90 mmHg

Exclusion Criteria

• Women of childbearing age must not be pregnant or breastfeeding at the time of the study
• BMI >35kg/m2
• Hypertensive as defined by brachial SBP >140mmHg and/or DBP >90mmHg
• Sensitivity to the study product or its sources
• Presence of chronic conditions or illnesses
• Having any gastrointestinal complication or condition
• Chronic use of dietary supplements that alter fat absorption

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
To compare 5 different dietary fat sources in a liquid meal on postprandial changes in augmentation index (AIx)	5 separate mornings, measurements taken at baseline and at 60, 120 and 180 minutes

Secondary Outcome Measures

Name	Time	Method
To investigate whether these dietary fat sources will result in blood pressure changes and a differential glycemic response	5 separate mornings, blood pressure measurements will be taken at baseline, 60, 120 and 180 minutes. Blood samples will be taken at baseline 15, 30, 45, 60, 90 and 120 minutes

Trial Locations

Locations (1)

Risk Factor Modification Centre, St. Michael's Hospital; 🇨🇦 Toronto, Ontario, Canada