NCT01876394Unknown不适用
Acute Effects of Dietary Fats on Postprandial Vascular Function in Healthy Individuals: Pilot Double Blind, Randomized, Controlled Trial
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 24
- 试验地点
- 2
- 主要终点
- To compare 5 different dietary fat sources in a liquid meal on postprandial changes in augmentation index (AIx)
研究概览
简要总结
The purpose of the study is to examine the effect of consuming 50g of fat from 5 different sources (coconut, canola, grapeseed, chia, and butter) on arterial stiffness, blood pressure and blood glucose levels. It is hypothesized that butter will have the most detrimental effect on acute vascular function. Canola, grapeseed and chia oil with their decreased content of SFA are hypothesized to impair vascular function to a lesser extent.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 18-65 years
- •BMI < 30 kg/m2
- •Brachial systolic blood pressure ≤ 140 mmHg
- •Brachial diastolic blood pressure ≤ 90 mmHg
排除标准
- •Women of childbearing age must not be pregnant or breastfeeding at the time of the study
- •BMI >35kg/m2
- •Hypertensive as defined by brachial SBP >140mmHg and/or DBP >90mmHg
- •Sensitivity to the study product or its sources
- •Presence of chronic conditions or illnesses
- •Having any gastrointestinal complication or condition
- •Chronic use of dietary supplements that alter fat absorption
结局指标
主要结局
To compare 5 different dietary fat sources in a liquid meal on postprandial changes in augmentation index (AIx)
时间窗: 5 separate mornings, measurements taken at baseline and at 60, 120 and 180 minutes
次要结局
- To investigate whether these dietary fat sources will result in blood pressure changes and a differential glycemic response(5 separate mornings, blood pressure measurements will be taken at baseline, 60, 120 and 180 minutes. Blood samples will be taken at baseline 15, 30, 45, 60, 90 and 120 minutes)
研究者
研究点 (2)
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