eural correlates of stress-related gene-environment interactions

• Conditions: vulnerability for stress-related psychiatric disorders, such as depression, posttraumatic stress disorder, alcohol dependence; F32.9; F43.1; F10; Depressive episode, unspecified; Post-traumatic stress disorder; Mental and behavioural disorders due to use of alcohol

• Registration Number: DRKS00003604
• Lead Sponsor: Zentralinstitut für Seelische Gesundheit,Klinik für Psychiatrie und Psychotherapie des Kindes- und Jugendalters

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2012-03-12
• Study Completion: 2013-05-27
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 309

Inclusion Criteria

Current participants of the Mannheim Study of Children at Risk

Exclusion Criteria

Participants in the main study: current psychiatric disorder, psychiatric treatment, drug or alcohol abuse, neurological disorder and other serious medical conditions, left-handedness, metallic implants

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
effects of genes and environmental adversity on the structure, function and connectivity of neural circuits involved in emotion regulation and reward processing. In detail, the following assessments will be conducted: (i) structural neuroimaging (voxel-based morphometry), (ii) diffusion tensor imaging (DTI), and (iii) functional neuroimaging using three experimental paradigms to assess BOLD fMRI combined with EEG response during the execution of an emotional arousal (face matching) task, a response conflict and inhibition (flanker) task, and a reward task (differential conditioning paradigm).