Microtransplantation in Older Patients With Acute Myeloid Leukemia

Phase 2

Completed

• Conditions: Acute Myeloid Leukemia

• Registration Number: NCT02831192
• Lead Sponsor: The Affiliated Hospital of the Chinese Academy of Military Medical Sciences

Brief Summary

The purpose of this study is to see whether HLA-mismatched donor cells infusion with chemotherapy (microtransplantation，MST) could increase complete remission (CR) and improve survival in older patients with acute myeloid leukemia (AML)，the investigators conducted a prospective, multicenter clinical trial of HLA-mismatched MST to estimate outcomes and toxicities.

Detailed Description

Not available

Study Timeline

• Study Start: 2006-05
• Primary Completion: 2015-07
• Study Completion: 2015-07
• Status Verified: 2016-07
• Study First Submitted: 2016-07-03
• Study First Submitted QC: 2016-07-12
• Last Update Submitted: 2016-07-12
• Study First Posted: 2016-07-13
• Last Update Posted: 2016-07-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

• de novo acute myeloid leukemia
• age 60-90
• have HLA mismatched donor

Exclusion Criteria

• have no suitable donor or donor refused
• patient refused to accept donor cells

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Graft versus host disease	1 month

Secondary Outcome Measures

Name	Time	Method
leukemia free survival	2 years
complete remission rate	2 months
overall survival	2 years

Trial Locations

Locations (1)

Affiliated Hospital of Academy of Military Medical Sciences ,; 🇨🇳 Beijing, Beijing, China