Mechanism and Clinical research of Zhenganxifeng dispensing granule decoction for treatment of hypertension with Yin Deficiency and Yang Hyperactivity Syndrome based on network pharmacology

Phase 1

Conditions: Essential hypertension

Registration Number: ITMCTR2000003146

Lead Sponsor: Affiliated Hospital of Shandong University of TCM

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: All

Target Recruitment: Not specified

Inclusion Criteria

1. it conforms to the diagnostic criteria of essential hypertension in western medicine and the diagnostic criteria of Yin deficiency and Yang hyperactivity syndrome of vertigo; Hypertension was grade 1, and was diagnosed as essential hypertension (grade 1) with Yin deficiency and Yang hyperactivity after standard lifestyle intervention;
2. In the past 2 weeks, blood pressure was stable, without the treatment of traditional Chinese medicine or proprietary Chinese medicine, after the treatment of western medicine, blood pressure was still in hypertension level 1 patients.
3. aged between 18 and 75 years old;
4. Volunteer to participate in the experiment and sign the informed consent, and cooperate with various investigations and tests.

Exclusion Criteria

1. secondary hypertension, refractory hypertension, malignant hypertension, acute and subacute hypertension, white coat hypertension and unstable blood pressure;
2. pregnant and lactating women, women of child-bearing age do not agree to use contraceptive measures during the experiment;
3. Have mental illness, can't cooperate very well;
4. confirmed to have serious heart disease, severe neurosis and heart, liver, kidney insufficiency;
5. There are severe endocrine, hematopoietic system, liver, kidney and other primary diseases, malignant tumors, mental patients;
6. Uncorrected hyperthyroidism, hypothyroidism; Patients with nephrotic syndrome, diabetes mellitus and acute hepatobiliary disease;
7. people who have suffered from serious cerebrovascular accidents, heart diseases, severe trauma, major surgery and other primary diseases with unstable general conditions and poor prognosis within 6 months;
8. Complicated with other diseases and is receiving medication treatment.

Study & Design

Study Type: Interventional study

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Ventricular brachial artery blood pressure;Quality of life score;24-hour dynamic blood pressure monitoring;symptom score of TCM;ADRA1A \ADRA1B\NOS3\MAOB;

Secondary Outcome Measures