Brain Connectivity Measured With High-density Electroencephalography
- Conditions
- Stroke
- Interventions
- Device: Connectivity measures
- Registration Number
- NCT06298097
- Lead Sponsor
- IRCCS San Camillo, Venezia, Italy
- Brief Summary
Emerging scientific results show that disrupted functional connectivity in stroke can explain behavioral impairments and predict their recovery over time. However, no technique is yet available for widespread use in clinics to examine how neural synchronization in brain networks is altered in stroke patients. This is crucial to determine favorable prognostic factors and to define individualized rehabilitation protocols. Importantly, the investigators have successfully used high-density electroencephalography (hdEEG) in healthy individuals to measure neural synchronization in brain networks. In this project, the investigators will develop methods and tools based on hdEEG for assessing functional connectivity in stroke patients. These methods and tools will be employed to examine how neural changes occurring after brain lesions explain behavioral impairments. The project will open the way for the use of hdEEG at the patient's bedside, as a neurodiagnostic tool for stroke as well as other brain disorders.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 170
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description stroke patients Connectivity measures Resting-state networks obtained through electroencephalography will be analyzed in a group of stroke patients. healthy participants Connectivity measures Resting-state networks obtained through electroencephalography will be analyzed in a group of healthy participants.
- Primary Outcome Measures
Name Time Method Magnetic Resonance Imaging measurement (work package 1, 2, and 3) 6 months after the recruiting Magnetic Resonance Imaging will be conducted using a 3 Tesla scanner. Specifically, T1-weighted Magnetic Resonance Imaging measure will be collected
High-density electroencephalography measurements (work package 1, 2, and 3) 6 months after the recruiting High-density electroencephalography measurements, specifically focusing on resting state networks, will be performed using either a 128-channel or a 256-channel system
- Secondary Outcome Measures
Name Time Method Funtional skills measurement (work package 3). 6 months after the recruiting Functional skills will be measured in the patients by using the Functional Independence Measure index. Six domains of function are evaluated: self-care, sphincter control, transfers, locomotion, communication, and social cognition. Self-care activities include dressing, eating, grooming, and bathing.
Cognitive performance measurements (work package 3) 6 months after the recruiting Cognitive functions will be measured in the patients by using the Oxford Cognitive Screen
Spasticity measurement (work package 3) 6 months after the recruiting Spasticity will be measured in the patients by using the Modified Ashworth Score
Muscle strength measurement (work package 3) 6 months after the recruiting Muscle strength will be measured in the patients by using the Medical Research Council Score
Sensorimotor impairment measurement (work package 3) 6 months after the recruiting Sensorimotor impairment will be measured in the patients by using the Upper Extremity Fugl-Meyer index
Activities of daily living measurement (work package 3) 6 months after the recruiting Activities of daily living will be measured in the patients by the Barthel Index
Pain measurement (work package 3) 6 months after the recruiting Pain level will be measured in the patients by the Visual Analog Scale for Pain
Trial Locations
- Locations (1)
IRCCS San Camillo Hospital
🇮🇹Venice, Italy