B12 Effect of supplementation and pulmonary rehabilitation in aerobic performance in patients with chronic obstructive pulmonary disease: a randomized study

Not Applicable

Recruiting

• Conditions: chronic obstructive pulmonary disease; J44.8

• Registration Number: RBR-55f97c
• Lead Sponsor: niversidade Federal de Mato Grosso do Sul - UFMS

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-07-14
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: Not specified

Inclusion Criteria

Volunteers with chronic obstructive pulmonary disease stages III and IV of the GOLD second disease; both sexes ; aged between 40 and 80 years ; at least four weeks free of disease exacerbation ; former smokers ; Current diagnosis or without other cardiopulmonary conditions such as asthma , interstitial lung disease , pulmonary hypertension , cardiac insufficiency or arthropathy , which does not allow exercise tests .

Exclusion Criteria

Volunteers with Chronic Obstructive Pulmonary Disease stages I and II of the disease according to GOLD criteria; participating in any program
cardiopulmonary rehabilitation ; which show no ability to perform pulmonary function tests, gradual or exhaustive effort load
constant; Volunteers with heart disease, dilated bronchi , rheumatic diseases , physical deformities that prevent the achievement of exercise or
that are not available to participate.

Study & Design

• Study Type: Intervention
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
It is expected from the improvement of functional capacity in patients with COPD, after eight weeks of periodized physical activity and <br>vitamin B12 supplementation. <br>For this purpose, will be examined through blood sample dosage of Vitamin B12 and through cardiopulmonary exercise testing constant load exercise time and the kinetic analysis during exercise. <br>The variables are presented as mean and standard deviation and also confidence interval of 95%. In all cases a significance level of 5% will be adopted.

Secondary Outcome Measures

Name	Time	Method
Once the physical capacity is considered an important marker in the development of COPD, multidimensional assessment, associating pulmonary variables and functional capacity, enables safe and effective interventions as well as more targeted pulmonary rehabilitation for this population, in addition to obtaining data that future may be taken into account in clinical variations <br>important post-intervention measurements, when one takes into account many factors that affect exercise capacity.