Genetics of Uveitis

Recruiting

• Conditions: Uveitis; Infectious Uveitis

• Registration Number: NCT02357238
• Lead Sponsor: The Cleveland Clinic

Brief Summary

In order to improve the investigators knowledge about uveitis and the underlying mechanism of disease, the investigators propose collecting blood from patients with uveitis, isolating DNA and sequencing the DNA to identify genetic mutations or associations in these patients.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-01
• Study First Submitted: 2015-02-03
• Study First Submitted QC: 2015-02-05
• Study First Posted: 2015-02-06
• Status Verified: 2025-04
• Last Update Submitted: 2025-04-30
• Last Update Posted: 2025-05-02
• Primary Completion: 2030-01
• Study Completion: 2030-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 1500

Inclusion Criteria

• Any patient above with the diagnosis of uveitis.
• Any patient with a diagnosis of infectious uveitis such as toxoplasmosis retinochoroiditis, herpes associated retinitis.

Exclusion Criteria

• Patients who are unable to give consent
• Patients in whom an adequated blood sample can not be obtained.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Non infectious uveitis	5 years	Distinct uveitis conditions will have a polymorphism association or specific mutation.

Secondary Outcome Measures

Name	Time	Method
Infectious uveitis	5 years	Infectious uveitis (such as herpes associated uveitis, toxoplasmosis retinochoroiditis) will have specific polymorphisms/mutations in innate immune system genes which predispose the patient to infectious uveitis.

Trial Locations

Locations (1)

Cleveland Clinic Foundation; 🇺🇸 Cleveland, Ohio, United States