Quantifying the effect and variability of neuromuscular blocking drugs on patients undergoing surgery.
Not Applicable
Completed
- Conditions
- surgery.Anaesthesiology - Other anaesthesiologyanaesthesia
- Registration Number
- ACTRN12619000664145
- Lead Sponsor
- Christchurch Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 63
Inclusion Criteria
Patients having surgeries lasting more than 60 minutes, who require more than one dose of rocuronium muscle relaxant.
Exclusion Criteria
Patients having surgery that will last for less than 60 minutes.
Patients having surgery that will require fewer than 2 doses of neuromuscular blockade NMB).
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Quantifying patient requirement for NMB during anaesthesia, using Train of Four (TOF) monitoring. <br>[Point of administration of NMB.];Patient quality of recovery in Post Anaesthetic Care Unit (PACU), as determined by the PQRS (Post-Operative Quality of Recovery Scale) that evaluates physiological, nociceptive, functional, cognitive and emotional recovery domains, as well as overall patient perspective.[Within 30 minutes of last stitch (i.e.last surgical stitch).];Patient quality of recovery in Post Anaesthetic Care Unit (PACU), as determined by the PQRS (Post-Operative Quality of Recovery Scale) that evaluates physiological, nociceptive, functional, cognitive and emotional recovery domains, as well as overall patient perspective.[Day 1 post-surgery.]
- Secondary Outcome Measures
Name Time Method Combined TOF ratio and NMB drug level at the time of last NMT measurement, as assessed by the Aisys Anaesthetic Machine.(Composite outcome.)[Time of last NMT measurement.];Peak drug level at disappearance of T1, as assessed by the Aisys Anaesthetic Machine.[Disappearance of T1.];Calculated NMB drug level at the time the second twitch (T2) of a train-of-four (TOF) returns, assessed by Aisys Anaesthetic Machine..[Return of T2.];Time from first dose of NMB to disappearance of T1 as assessed by Aisys Anaesthetic Machine. (TOF ratio is used in monitoring recovery from neuromuscular block.. T1 is the first indicator of early return of neuromuscular function.)[Disappearance of T1.];Combined (composite)Train of Four (TOF) and drug level at the time any NMB antagonist is administered, as shown by Aisys Anaesthetic Machine.[At administration of NMB antagonist.]