Towards novel BIOmarkers to diagnose SEPsis on the emergency room

Recruiting

• Conditions: Sepsis; Blood poisoning; 10004018

• Registration Number: NL-OMON51785
• Lead Sponsor: Amsterdam UMC

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 8 July 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 3120

Inclusion Criteria

Suspected infections with increased MEWS score

Exclusion Criteria

No informed consent provided

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>• SOFA and MEWS score collected on and during admission;<br /><br>• Sepsis at (ED and/or hospital and/or ICU) admission;<br /><br>• Final diagnosis for hospitalization;<br /><br>• Assessment of the host immune response by Raman spectroscopy,<br /><br>transcriptomics, proteomics, lipidomics, metabolomics, and gut microbiota. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>• Duration of hospital stay;<br /><br>• Duration of ICU stay;<br /><br>• Hospital mortality;<br /><br>• ICU mortality;<br /><br>• 28-day mortality;<br /><br>• 60-day mortality;<br /><br>• 1-year mortality;<br /><br>• Sequelae of sepsis up to 60-days post admission (decreased executive<br /><br>functions, weakness, fatigue, mood, etc.);<br /><br>• All-cause readmissions in the first year after discharge. </p><br>