AI-Powered Research

* Patients 18 years or older
* Symptomatic knee osteoarthritis according to the American College of Rheumatology classification criteria (Wu et al, 2005). Radiographic disease severity will be evaluated for each participant (Kellgren-Lawrence 0-4 grading scale).
* Scheduled for an elective unilateral total knee arthroplasty (TKA) no sooner than 2 weeks from the time of recruitment
* Be able to understand and speak Dutch language
* Patient is willing and able to complete scheduled study procedures and follow-up evaluations.
* Provide written informed consent

Exclusion Criteria

* Scheduled for revision arthroplasty
* Diagnosis of inflammatory arthritis (i.e. rheumatoid arthritis, psoriatic arthritis, systemic lupus erythematosis, ankylosing spondylitis)
* Scheduled for TKA because of a fracture, malignancy or an infection
* Patient is currently participating in any other surgical intervention studies or pain management studies
* Previous total knee arthroplasty or any other lower limb surgery within the past six months
* Cognitive impairment

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary outcome will be the change in Western Ontario and McMaster<br /><br>Universities Osteoarthritis Index (WOMAC) pain scale score 3 months following<br /><br>surgery. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secundary study parameters are the level of pain catastrophizing thoughts,<br /><br>assessed with the Pain Catastrophizing Scale Dutch Version (PCS-DV),<br /><br>preoccupation with pain, assessed with the Pain Vigilance and Attention<br /><br>Questionnaire (PVAQ) and presence and severity of anxiety and depression are<br /><br>determined with the Hospital Anxiety and Depression Scale.<br /><br>Disease specific and general health related quality of life is assessed with<br /><br>the RAND-36 and WOMAC, subscale stiffness and physical functioning.<br /><br>Patient parameters are gathered and include demographic information, BMI,<br /><br>duration of kneepain, osteoarthiritis severity graded by Kellgren-Lawrence 0*4<br /><br>grading scale, the number of visits to healthcare providers, other than the<br /><br>visits related to the TKA and use of analgesic medication.</p><br>