Dexmedetomidine Added to Bupivacaine Versus Bupivacaine inTransincisionalU/S Guided Quadratus Lumborum Block in Open Renal Surgeries , A New Technique :Prospective, Randomized Double- Blinded Study
Trial Snapshot
- Phase
- Phase 4
- Status
- Completed
- Sponsor
- Ain Shams University
- Enrollment
- 80
- Locations
- 1
- Primary Endpoint
- First time to analgesic requirement
Study Overview
Brief Summary
The purpose of this study is to compare the addition of dexmedetomidine to bupivacaine versus bupivacaine only in anterior QLblock(transincisional) , where the local anesthetic will be applied before wound closure at the end of surgery through the wound . in combination with general anesthesia in elective open renal surgery with regard to Postoperative pain control,hemodynamic stability, and adverse effects.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Eligibility Criteria
- Ages
- 20 Years to 65 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •physical status American Society of Anesthesiologist (ASA) I or II
Exclusion Criteria
- •Patients refusal
- •A body mass index (BMI) >30 kg/m2
- •ASA physical status >II
- •major illnesses (e.g., cardiac, respiratory, renal, hepatic or neurological)
- •Coagulation abnormalities
- •Infection at the injection site
- •Allergy or contraindications to the drugs used in the study
- •History of drug addiction or alcohol abuse
- •A psychiatric illness, or mental retardation interfering with the evaluation of pain scores or PCA programs .
Arms & Interventions
quadratus lumborum block(dexmedetomidine+bupivacaine)
patients will receive combined general anesthesia and Quadratuslumborum block( transincisional ie before wound closure)with 19 mL of bupivacaine 0.20%plus 1 mic/kg of dexmedetomidine ,total volume 20 ml.
Intervention: Dexmedetomidine +bupivacaine (Drug)
quadratus lumborum block(bupivacaine)
patients will receive combined general anesthesia and quadratus lumborum block (transincisional) with 20 ml of bupivacaine 0.20%.
Intervention: Bupivacaine (Drug)
Outcomes
Primary Outcomes
First time to analgesic requirement
Time Frame: 1st 24 hour postoperatively
After extubation, an intravenous patient - controlled system, will be connected to the patient (Accufuser plus 100 ml) will be prepared with 60 ml isotonic saline containing 60 mg morphine , it will be programmed to give 0.5 ml bolus dose with lockout interval of 8 minutes. Time to first bolus will be recorded considering extubation time is the zero time
Secondary Outcomes
- the secondary outcomes will be the total opioid consumption postoperatively(1st 24 hour)
Investigators
Amin Mohammed Alansary Amin Ahmed Helwa
Assistant professor
Ain Shams University