Effect of the Addition of Dexmedetomidine to Bupivacaine During Supraclavicular Brachial Plexus Blockade

Phase 4

Completed

• Conditions: Sequelae of Fracture of Forearm and Upper Arm
• Interventions: Drug: dexmedetomidine; Drug: bupivacaine

• Registration Number: NCT02049970
• Lead Sponsor: TC Erciyes University

Brief Summary

the aim of this study was effect of the addition of dexmedetomidine to bupivacaine during supraclavicular brachial plexus blockade for forearm surgery, by low doses bupivacaine providing prolonged analgesia after surgery.

Detailed Description

Anaesthesia for surgeries to the upper extremity commonly is provided using brachial plexus anaesthesia.Various local anaesthetic mixtures can be used to prolong local anaesthesia duration and epinephrine , opioids and dexmedetomidine are frequently used for this purpose. this study was conducted to compare the effects of adding dexmedetomidine to local anaesthetics in the supraclavicular brachial plexus block by using nerve stimulators and ultrasonography guided. dexmedetomidine has also been found the prolong the duration of bupivacaine infraclavicular brachial plexus block.

Study Timeline

• Study Start: 2014-01
• Study First Submitted: 2014-01-28
• Study First Submitted QC: 2014-01-28
• Study First Posted: 2014-01-30
• Status Verified: 2014-11
• Primary Completion: 2014-11
• Study Completion: 2014-11
• Last Update Submitted: 2014-11-07
• Last Update Posted: 2014-11-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 44

Inclusion Criteria

• 18-65 age
• unwanted general anaesthesia
• ASA 1-2
• single forearm, arm surgery

Exclusion Criteria

• major psychiatric problems
• major neurologic deficits
• coagulopathy
• drug allergies
• chronic analgesic used

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
dexmedetomidine and bupivacaine	dexmedetomidine	Bupivacaine 50 mg and dexmedetomidine 1 microgram/kg
Bupivacaine and placebo	dexmedetomidine	Bupivacaine 100 mg and SF 10 ml
dexmedetomidine and bupivacaine	bupivacaine	Bupivacaine 50 mg and dexmedetomidine 1 microgram/kg
Bupivacaine and placebo	bupivacaine	Bupivacaine 100 mg and SF 10 ml

Primary Outcome Measures

Name	Time	Method
the duration of sensorial block	postoperative 1 day	pin-prick test

Secondary Outcome Measures

Name	Time	Method
the first time analgesic required	postoperative 1 day

Trial Locations

Locations (1)

Erciyes University Medical Faculty; 🇹🇷 Kayseri, Turkey