euronal communication in Autism Spectrum Disorders: synchrony and coherence in the motor system

Withdrawn

• Conditions: autism; Pervasive developmental disorder; 10012562

• Registration Number: NL-OMON32406
• Lead Sponsor: niversitair Medisch Centrum Sint Radboud

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Withdrawn
• Sex: Not specified
• Target Recruitment: 60

Inclusion Criteria

(1) To be included in the Autism Spectrum Disorders- group the participant should meet criteria for Autistic disorder or Asperger Disorder as specified in the DSM-IV. To be included in the ADHD-group the participant should meet criteria for ADHD as specified in the DSM-IV. (2) Age between 8 and 18 years old.

Exclusion Criteria

ASD-group: Co-morbid neuropsychiatric disorders like ADHD, tic-disorders and epilepsy.
ADHD-group: Co-morbid neuropsychiatric disorders like ASD, tic-disorders and epilepsy.
Typically developed group: neuropsychiatric disorders like ASD, ADHD, tic-disorders and epilepsy.

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>(1) Time-frequency analyses will be applied to calculate MEG power in a given<br /><br>frequency band (beta), over a given timeinterval for a given group of sensors.<br /><br>Mean beta-power will be calculated for each group and compared between groups.<br /><br>(2) Coherence between MEG signals recorded over motorcortex and EMG signals<br /><br>recorded at the right first dorsal interosseus (FDI) muscle will be calculated.<br /><br>Mean coherence for a given time and frequency interval will be calculated for<br /><br>each group and comparisons will be made.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>not applicable</p><br>