Thumb Muscle Thickness and Strength in CMC Osteoarthritis

Completed

• Conditions: Osteoarthritis

• Registration Number: NCT06730698
• Lead Sponsor: Beylikduzu State Hospital

Brief Summary

A total of 34 patients aged between 50-80 years, diagnosed with first carpometacarpal joint osteoarthritis based on hand radiographs taken within the last 3 months, will be included in the study from the Physical Therapy and Rehabilitation outpatient clinic. Sociodemographic data such as age, gender, height, weight, and BMI will be recorded. Based on their current radiographs, patients will be classified into two groups according to the Eaton-Littler classification: Stage 1-2 (early stage) and Stage 3-4 (advanced stage). Pain levels will be assessed using the Visual Analog Scale (VAS). Hand grip strength will be evaluated with a Jamar hand dynamometer, and pinch grip strength will be assessed with a Jamar pinch meter. The thicknesses of the abductor pollicis brevis, first dorsal interosseous, and opponens pollicis muscles will be measured using ultrasound. All assessments will be performed separately for the dominant and non-dominant hands.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2024-12-09
• Study First Submitted QC: 2024-12-09
• Study Start: 2024-12-10
• Study First Posted: 2024-12-12
• Primary Completion: 2025-01-20
• Study Completion: 2025-01-20
• Status Verified: 2025-03
• Last Update Submitted: 2025-03-22
• Last Update Posted: 2025-03-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 34

Inclusion Criteria

• Patients aged 50-80 years.
• Diagnosed with first carpometacarpal joint osteoarthritis.
• Presence of a hand radiograph taken within the last 3 months.
• Volunteered to participate in the study.

Exclusion Criteria

• Refusal to participate in the study.
• Use of medications that may suppress osteoarthritis flares.
• Presence of rheumatologic diseases causing peripheral joint involvement.
• History of fractures or surgeries involving the first carpometacarpal joint.
• Presence of psychiatric disorders.
• Presence of cognitive impairments that could hinder understanding or performance of study-related tasks.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Thumb Muscle Thickness (Ultrasound)	0 day	Measurement of the thickness of three thumb muscles-abductor pollicis brevis, first dorsal interosseous, and opponens pollicis-using ultrasonography. These measurements will help determine muscle atrophy or hypertrophy related to disease severity and stage

Secondary Outcome Measures

Name	Time	Method
Grip Strength	0 day	Assessed using a Jamar hand dynamometer. This measure evaluates overall hand strength, which is often impaired in advanced stages of carpometacarpal joint osteoarthritis.
Pinch Strength	0 day	Assessed using a Jamar pinch meter. This measure evaluates the strength of the thumb-index finger pinch, a critical function for fine motor activities. It is particularly relevant to functional limitations seen in osteoarthritis.
Pain Level (VAS)	0 day	Pain intensity will be measured using the Visual Analog Scale (VAS). Patients will mark their perceived pain level on a 10 cm scale, providing a quantitative measure of pain severity in both early and advanced stages.

Trial Locations

Locations (1)

Beylikdüzü State Hospital; 🇹🇷 Istanbul, Beylikdüzü, Turkey